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How to get fromKey Largo to Knoxvilleby shuttle, plane, bus, taxi, or car

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There are 7 ways to get from Key Largo to Knoxville by shuttle, plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Miami International Airport, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    4h 41m
    $315–1,046

  2. Drive  901.4 mi

    cheapest
    1. Drive from Key Largo to Knoxvillecar car 901.4 mi
    15h 55m
    $165–238

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville to Winston-Salembus bus
    4. Take the bus from Winston-Salem to Boonebus bus
    5. Take the taxi from Boone to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Chilhowee at Holstoncar car
    30h 43m
    $439–559

  4. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    5h 7m
    $372–1,315

  5. Bus to Key West International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Key Largo Bus Stop to Key West Airportbus bus
    2. Fly from Key West International Airport (EYW) to Mcghee Tyson Airport (TYS)plane plane EYW - TYS
    6h 35m
    $262–1,195

  6. Shuttle to Miami International Airport, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Asheville Regional Airport (AVL)plane plane MIA - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 35m
    $192–511

  7. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Asheville Regional Airport (AVL)plane plane FLL - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 58m
    $224–610

Miami International Airport (MIA) to Mcghee Tyson Airport (TYS) flights

Calendar24Weekly Planes
Duration3h 48mAverage Duration
Ticket$158Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key Largo to Knoxville.ExpandLaunch map view
  • Distance: 797.1 mi
  • Duration: 4h 41m

What companies run services between Key Largo, FL, USA and Knoxville, TN, USA?

There is no direct connection from Key Largo to Knoxville. However, you can take the shuttle to Miami, FL - International Airport, walk to Miami International Airport (MIA) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take the bus to Miami Airport Station, take the bus to Fayetteville Bus Station, take the bus to Winston-Salem, take the bus to Boone, take the taxi to Black Bear Resort, take the shuttle to Hot Springs, drive to Chilhowee at Holston, then take the line 31 bus to Knoxville Station Hall of Fame.

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