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How to get fromKey Largo to Knoxvilleby shuttle, plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 10 ways to get from Key Largo to Knoxville by shuttle, plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Miami International Airport, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    4h 50m
    $325–1,096

  2. Drive  901.4 mi

    cheapest
    1. Drive from Key Largo to Knoxvillecar car 901.4 mi
    15h 55m
    $155–223

  3. Bus via Farragut

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Port Authority Bus Terminalbus bus 108
    4. Take the bus from New York to Knoxvillebus bus Nyc
    42h 17m
    $412–629

  4. Bus, train via Farragut

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the train from Hollywood Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    44h 17m
    $947–1,475

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    5h 7m
    $392–1,415

  6. Bus to Key West International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Key Largo Bus Stop to Key West Airportbus bus
    2. Fly from Key West International Airport (EYW) to Mcghee Tyson Airport (TYS)plane plane EYW - TYS
    6h 35m
    $273–1,196

  7. Shuttle to Miami International Airport, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Asheville Regional Airport (AVL)plane plane MIA - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 42m
    $185–476

  8. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Asheville Regional Airport (AVL)plane plane FLL - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 57m
    $222–605

  9. Bus, train

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the train from Hollywood Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 21m
    $902–1,385

  10. Bus

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 40m
    $330–466

Miami International Airport (MIA) to Mcghee Tyson Airport (TYS) flights

Calendar44Weekly Planes
Duration4h 3mAverage Duration
Ticket$164Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key Largo to Knoxville.ExpandLaunch map view
  • Distance: 797 mi
  • Duration: 4h 50m

What companies run services between Key Largo, FL, USA and Knoxville, TN, USA?

You can take a bus from Key Largo Bus Stop to Knoxville via Miami Airport Station, Newark Penn Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 42h 17m.

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