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How to get fromKey Largo to Panama City Beachby bus, plane, bus (Greyhound), train, car, or shuttle

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There are 10 ways to get from Key Largo to Panama City Beach by bus, plane, bus (Greyhound), train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Miami International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Northwest Florida Beaches International Airport (ECP)plane plane MIA - ECP
    6h 55m
    $126–441

  2. Bus to Miami International Airport, fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 45m
    $71–341

  3. Bus via Miami Airport (MIA)

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    15h 39m
    $161–228

  4. Bus, train

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the train from Hollywood Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    19h 19m
    $295–463

  5. Drive  610 mi

    1. Drive from Key Largo to Panama City Beachcar car 610 mi
    11h 45m
    $105–151

  6. Bus to Miami International Airport, fly to Pensacola International Airport, drive

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Pensacola International Airport (PNS)plane plane MIA - PNS
    3. Drive from Pensacola-Airport-PNS to Panama City Beachcar car
    6h 43m
    $72–311

  7. Bus to Miami International Airport, fly to Tallahassee, bus

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane plane MIA - TLH
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    7h 26m
    $122–454

  8. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Pensacola International Airport, drive

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Pensacola International Airport (PNS)plane plane FLL - PNS
    3. Drive from Pensacola-Airport-PNS to Panama City Beachcar car
    7h 6m
    $283–460

  9. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Tallahassee, bus

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Tallahassee (TLH)plane plane FLL - TLH
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    7h 48m
    $288–813

  10. Bus (Greyhound)

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    19h 29m
    $139–216

Miami International Airport (MIA) to Northwest Florida Beaches International Airport (ECP) flights

Calendar70Weekly Planes
Duration5h 27mAverage Duration
Ticket$68Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key Largo to Panama City Beach.ExpandLaunch map view
  • Distance: 539.5 mi
  • Duration: 6h 55m

What companies run services between Key Largo, FL, USA and Panama City Beach, FL, USA?

You can take a bus from Key Largo Bus Stop to Panama City Beach via Miami, Airport Intermodal Station, Miami Airport Station, Miami International Airport, Miami Airport, Old St Augustine at Intramural Field, Tallahassee, and Panama City Beach Bus Station in around 15h 39m.

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