There are 4 ways to get from Key Largo to Port Saint Lucie by bus (Greyhound), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Pembroke Pines
best- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Sheridan Tri-Rail Station to Fort Piercebus Miami to Orlando
5h 20m$44–62Bus, train
cheapest- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Take the train from Miami Airport Station to West Palm Beach Stationtrain
- Take the bus from West Palm Beach Bus Station to Port St Luciebus
6h 46m$23–41Drive 175.1 mi
- Drive from Key Largo to Port Saint Luciecar 175.1 mi
3h 7m$30–44Bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami International Airport to Fort Piercebus Miami to Orlando
6h$41–56
Key Largo to Port Saint Lucie by bus
Comparing Your Travel Options
The cheapest way to get from Key Largo to Port Saint Lucie is to bus and train which costs $22 - $45 and takes 6h 46m.
The fastest way to get from Key Largo to Port Saint Lucie is to drive which takes 3h 7m and costs $29 - $45.
No, there is no direct bus from Key Largo to Port Saint Lucie. However, there are services departing from Key Largo Bus Stop and arriving at Fort Pierce via Miami Airport Station and Sheridan Tri-Rail Station. The journey, including transfers, takes approximately 5h 20m.
The distance between Key Largo and Port Saint Lucie is 178 miles. The road distance is 176.1 miles.
The best way to get from Key Largo to Port Saint Lucie without a car is to bus via Pembroke Pines which takes 5h 20m and costs $40 - $65.
It takes approximately 5h 20m to get from Key Largo to Port Saint Lucie, including transfers.
Key Largo to Port Saint Lucie bus services, operated by Greyhound USA, depart from Key Largo Bus Stop station.
Key Largo to Port Saint Lucie bus services, operated by Greyhound USA, arrive at Miami Airport Station.
Yes, the driving distance between Key Largo to Port Saint Lucie is 176 miles. It takes approximately 3h 7m to drive from Key Largo to Port Saint Lucie.
Book your Key Largo to Port Saint Lucie bus tickets online with Omio.
What companies run services between Key Largo, FL, USA and Port Saint Lucie, FL, USA?
You can take a bus from Key Largo Bus Stop to Fort Pierce via Miami Airport Station, Hollywood Sheridan Trirail Station, and Sheridan Tri-Rail Station in around 5h 20m.
- Phone
- +1 800-874-7245
- [email protected]
- Website
- Tri Rail
Train from Miami Airport Station to West Palm Beach Station
- Ave. Duration
- 1h 45m
- Frequency
- Hourly
- Estimated price
- $5–11
- Website
- Tri Rail
- Weekend | Holiday
- $5
- Weekday
- $8–11
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $10–16
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $10–16
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $10–16
- Website
- Greyhound
Bus from West Palm Beach Bus Station to Port St Lucie
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- $9–14
- Website
- Greyhound
- Phone
- (+1) 407 649 4994
- [email protected]
- Website
- Jet Set Express
Bus from Sheridan Tri-Rail Station to Fort Pierce
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Bus from Miami International Airport to Fort Pierce
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from West Palm Beach Bus Station to Port St Lucie
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $7–12
- Schedules at
- Flixbus USA
- Phone
- +1 561-841-4287
- [email protected]
- Website
- Palm Tran
Bus from West Palm Beach Bus Station to Port St Lucie
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- $2
- Website
- Palm Tran
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Booking & Getting There
There are 542+ hotels available in Port Saint Lucie.







