There are 4 ways to get from Key Largo to Port Saint Lucie by bus (Greyhound), car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Pembroke Pines
best- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Sheridan Tri-Rail Station to Fort Piercebus Miami to Orlando
5h 12m$42–60Bus #2
cheapest- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami Golden Glades to Port St Luciebus FlixBus N2411
6h 58m$27–44Drive 175.1 mi
- Drive from Key Largo to Port Saint Luciecar 175.1 mi
3h 7m$32–47Bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami International Airport to Fort Piercebus Miami to Orlando
6h$39–54
Key Largo to Port Saint Lucie by bus and train
Questions & Answers
The cheapest way to get from Key Largo to Port Saint Lucie is to bus which costs $27 - $45 and takes 6h 58m.
The fastest way to get from Key Largo to Port Saint Lucie is to drive which takes 3h 7m and costs $30 - $50.
No, there is no direct bus from Key Largo to Port Saint Lucie. However, there are services departing from Key Largo Bus Stop and arriving at Fort Pierce via Sheridan Tri-Rail Station. The journey, including transfers, takes approximately 5h 12m.
The distance between Key Largo and Port Saint Lucie is 176 miles. The road distance is 176.1 miles.
The best way to get from Key Largo to Port Saint Lucie without a car is to bus via Pembroke Pines which takes 5h 12m and costs $40 - $65.
It takes approximately 5h 12m to get from Key Largo to Port Saint Lucie, including transfers.
Key Largo to Port Saint Lucie bus services, operated by Greyhound USA, depart from Key Largo Bus Stop station.
Key Largo to Port Saint Lucie bus services, operated by Greyhound USA, arrive at Miami Airport Station.
Yes, the driving distance between Key Largo to Port Saint Lucie is 176 miles. It takes approximately 3h 7m to drive from Key Largo to Port Saint Lucie.
Book your Key Largo to Port Saint Lucie bus tickets online with Omio.
What companies run services between Key Largo, FL, USA and Port Saint Lucie, FL, USA?
You can take a bus from Key Largo Bus Stop to Fort Pierce via Miami, Airport Intermodal Station, Miami Airport Station, Sheridan Street Station, and Sheridan Tri-Rail Station in around 5h 12m.
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 3 times a day
- Estimated price
- $9–15
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 3 times a day
- Estimated price
- $9–15
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 20m
- Frequency
- 3 times a day
- Estimated price
- $9–15
- Website
- Greyhound
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More Questions & Answers
There are 528+ hotels available in Port Saint Lucie.


