Rome2Rio

How to get fromKey Largo to Sanibel Islandby bus, taxi, ferry, car, shuttle, plane, or bus (Greyhound, Flixbus)

Find Transport to Sanibel Island

See all options

There are 5 ways to get from Key Largo to Sanibel Island by bus, taxi, ferry, car, shuttle, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi

    best
    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport to Naples, FLbus bus
    3. Take the taxi from Naples, FL to Sanibel Islandtaxi taxi
    5h 27m
    $169–219
  2. Drive  181.5 mi

    cheapest
    1. Drive from Key Largo to Sanibel Islandcar car 181.5 mi
    3h 54m
    $34–48
  3. Bus, ferry

    1. Take the bus from Key Largo Bus Stop to Big Pine Keybus bus
    2. Take the bus from Big Pine Key - CVS / MM30 to Caroline & Grinnellbus bus Lks
    3. Take the ferry from Key West, FL to Fort Myers Beach, FLferry ferry
    9h 51m
    $173–191
  4. Shuttle, fly, bus

    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Sarasota–Bradenton International Airport (SRQ)plane plane MIA - SRQ
    3. Take the bus from Sarasota Cattlemen Transfer Center to Fort Myers Bus Stopbus bus
    7h 10m
    $242–691
  5. Bus

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Fort Myers Bus Stopbus bus FlixBus 2421
    7h 38m
    $73–112

Miami International Airport (MIA) to Sarasota–Bradenton International Airport (SRQ) flights

Calendar7Weekly Planes
Duration1h 6mAverage Duration
Ticket$66Cheapest Price
See schedules

Comparing Your Travel Options

What companies run services between Key Largo, FL, USA and Sanibel Island, FL, USA?

You can take a bus from Key Largo Bus Stop to Sanibel Island via Miami Airport Station, Rosa Parks Transportation Ctr, and Cape Coral Transfer Center in around 7h 38m.

Airlines
Bus operators
Ferry operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound