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How to get fromKey West, FL to Jacksonvilleby plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Key West, FL to Jacksonville by plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville

    best
    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    6h 9m
    $147–510

  2. Bus, train via Orlando

    cheapest
    1. Take the bus from Whitehead & Eaton to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Orlando Bus Stationbus bus
    5. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    15h 8m
    $81–135

  3. Shuttle, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Orlando - RedCoach Station, FLbus bus
    3. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    14h 9m
    $252–315

  4. Bus, train

    1. Take the bus from Whitehead & Southard to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Jacksonvilletrain train
    16h 17m
    $251–402

  5. Drive  504.3 mi

    1. Drive from Key West, FL to Jacksonvillecar car 504.3 mi
    9h 12m
    $84–121

  6. Fly to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    4h 38m
    $146–437

  7. Fly to Gainesville Regional Airport, bus

    1. Fly from Key West International Airport (EYW) to Gainesville Regional Airport (GNV)plane plane EYW - GNV
    2. Take the bus from Gainesville to Jacksonvillebus bus
    9h 10m
    $143–456

  8. Bus

    1. Take the bus from Whitehead & Eaton to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Jacksonvillebus bus
    15h 48m
    $90–149

Key West, FL to Jacksonville by shuttle and bus

Calendar21Weekly Services
Duration14h 9mAverage Duration
Ticket$252Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West, FL to Jacksonville.ExpandLaunch map view
  • Distance: 432.1 mi
  • Duration: 6h 9m

What companies run services between Key West, FL, USA and Jacksonville, FL, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Jacksonville (JAX) every 4 hours. Alternatively, you can take a bus from Whitehead & Eaton to Jacksonville via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 15h 48m.

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