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How to get fromKey West (Island) to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or ferry

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There are 6 ways to get from Key West (Island) to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, car, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville

    best
    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    5h 47m
    $361–787

  2. Fly to Orlando Sanford, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    3h 33m
    $66–304

  3. Bus

    1. Take the bus from Key West Airport to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Jacksonvillebus bus FlixBus 2431
    14h
    $135–192

  4. Bus, train

    1. Take the bus from Key West Airport to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the train from Hollywood Amtrak Station to Jacksonvilletrain train Silver Meteor / ...
    15h 30m
    $169–331

  5. Drive 502.8 mi

    1. Drive from Key West to Jacksonvillecar car 502.8 mi
    9h 8m
    $92–133

  6. Ferry, bus

    1. Take the ferry from Key West, FL to Fort Myers Beach, FLferry ferry
    2. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    17h 10m
    $191–239

Key West (Island) to Jacksonville by bus

Calendar22Weekly Buses
Duration14hAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Key West (Island) to Jacksonville.ExpandLaunch map view
  • Distance: 428.1 mi
  • Duration: 5h 47m

What companies run services between Key West (Island), FL, USA and Jacksonville, FL, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Jacksonville (JAX) every 4 hours. Alternatively, you can take a bus from Key West Airport to Jacksonville via Miami Airport Station in around 14h.

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