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How to get fromKey West (Island) to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or ferry

Find Transport to Jacksonville

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There are 6 ways to get from Key West (Island) to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, car, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville

    best
    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    5h 35m
    $64–380

  2. Bus

    1. Take the bus from Key West Airport to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Jacksonvillebus bus FlixBus 2431 / ...
    14h 25m
    $85–148

  3. Bus, train

    1. Take the bus from Key West Airport to Miami Airport Stationbus bus
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the train from Fort Lauderdale Amtrak Station to Jacksonvilletrain train
    15h 28m
    $125–277

  4. Drive  502.8 mi

    1. Drive from Key West to Jacksonvillecar car 502.8 mi
    9h 8m
    $92–133

  5. Fly to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    3h 30m
    $67–330

  6. Ferry, bus

    1. Take the ferry from Key West, FL to Fort Myers Beach, FLferry ferry
    2. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    17h 15m
    $184–224

Key West (Island) to Jacksonville by bus

Calendar19Weekly Buses
Duration14h 25mAverage Duration
Ticket$85Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West (Island) to Jacksonville.ExpandLaunch map view
  • Distance: 428.1 mi
  • Duration: 5h 35m

What companies run services between Key West (Island), FL, USA and Jacksonville, FL, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Jacksonville (JAX) every 4 hours. Alternatively, you can take a bus from Key West Airport to Jacksonville via Miami Airport Station in around 14h 25m.

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