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How to get fromKey West to Charlestonby plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Find Transport to Charleston

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There are 5 ways to get from Key West to Charleston by plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Key West International Airport (EYW) to Charleston International Airport (CHS)plane plane EYW - CHS
    5h 34m
    $284–516

  2. Bus

    cheapest
    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami to Savannah Bus Stationbus bus
    4. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    22h 12m
    $136–239

  3. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train
    20h 44m
    $265–520

  4. Drive 740.7 mi

    1. Drive from Key West to Charlestoncar car 740.7 mi
    13h 15m
    $136–196

  5. Shuttle, bus, train

    1. Take a shuttle bus from Key West, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Take the bus from Fort Lauderdale Airport to West Palm Beach, FLbus bus
    3. Take the train from West Palm Beach Amtrak Station to Charleston Amtrak Stationtrain train
    22h 9m
    $398–640

Key West to Charleston by bus, foot, and taxi

Calendar3Weekly Services
Duration22h 12mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Key West to Charleston.ExpandLaunch map view
  • Distance: 601.3 mi
  • Duration: 5h 34m

What companies run services between Key West, FL, USA and Charleston, SC, USA?

American Airlines, Delta, and United Airlines fly from Key West International Airport (EYW) to Charleston International Airport (CHS) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Transit Mall via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami, Airport Intermodal Station, Miami, Savannah Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 22h 12m.

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