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How to get fromKey West to Columbiaby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Key West to Columbia by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia

    best
    1. Fly from Key West International Airport (EYW) to Columbia (CAE)plane plane EYW - CAE
    6h 24m
    $174–866

  2. Bus

    cheapest
    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Savannah Bus Stationbus bus
    5. Take the bus from Savannah Bus Station to Sumter Bus Stopbus bus
    6. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Senate Northbus bus 44
    25h 32m
    $130–240

  3. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Columbia Stationtrain train
    24h 16m
    $265–550

  4. Drive 791 mi

    1. Drive from Key West to Columbiacar car 791 mi
    13h 48m
    $145–209

  5. Fly to Augusta Regional Airport At Bush Field, bus

    1. Fly from Key West International Airport (EYW) to Augusta Regional Airport At Bush Field (AGS)plane plane EYW - AGS
    2. Take the bus from Augusta to Columbia, SCbus bus
    8h 4m
    $148–466

  6. Fly to Savannah, train

    1. Fly from Key West International Airport (EYW) to Savannah (SAV)plane plane EYW - SAV
    2. Take the train from Savannah Station to Columbia Stationtrain train
    7h 37m
    $457–804

Key West to Columbia by bus, foot, and train

Calendar7Weekly Services
Duration24h 16mAverage Duration
Ticket$265Cheapest Price
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Questions & Answers

Map of how to get from Key West to Columbia.ExpandLaunch map view
  • Distance: 661.1 mi
  • Duration: 6h 24m

What companies run services between Key West, FL, USA and Columbia, SC, USA?

American Airlines, Delta, and United Airlines fly from Key West International Airport (EYW) to Columbia (CAE) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Assembly Senate North via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Ft Lauderdale Broward Park & Ride, Savannah Bus Station, Sumter Bus Stop, and James E Clyburn Intermodal Transportation Center in around 25h 32m.

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