There are 5 ways to get from Key West to Des Moines by plane, bus, train, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Key West International Airport (EYW) to Des Moines (DSM)plane EYW - DSM
5h 20m$209–835Bus, train
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus Lks
- Take the bus from Big Pine Key to Miami Airport Stationbus
- Take the train from Miami Amtrak Station to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
2d 13h$633–1,452Bus, train via Newark
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus Lks
- Take the bus from Big Pine Key to Miami Airport Stationbus
- Take the train from Miami Amtrak Station to Newark Penn Stationtrain
- Take the bus from Newark Penn Station to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Des Moinesbus
2d 14h$563–1,242Drive 1,682.5 mi
- Drive from Key West to Des Moinescar 1,682.5 mi
30h 21m$307–444Shuttle, train, bus
- Take a shuttle bus from Key West, FL to Miami, FL - International Airport
- Take the train from Miami Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain
- Take the bus from Galesburg to Des Moinesbus
2d 14h$816–1,689
Key West to Des Moines by bus, foot, taxi, and train
Questions & Answers
The cheapest way to get from Key West to Des Moines is to drive which costs $300 - $450 and takes 30h 21m.
The fastest way to get from Key West to Des Moines is to fly which takes 5h 20m and costs $200 - $850.
The distance between Key West and Des Moines is 1374 miles. The road distance is 1692.3 miles.
The best way to get from Key West to Des Moines without a car is to bus and train which takes 2 days 13h and costs $600 - $1,500.
It takes approximately 5h 20m to get from Key West to Des Moines, including transfers.
Des Moines is 1h behind Key West. It is currently 6:54 PM in Key West and 5:54 PM in Des Moines.
Yes, the driving distance between Key West to Des Moines is 1692 miles. It takes approximately 30h 21m to drive from Key West to Des Moines.
There are 266+ hotels available in Des Moines.
What companies run services between Key West, FL, USA and Des Moines, IA, USA?
Delta, United Airlines, and two other airlines fly from Key West International Airport (EYW) to Des Moines (DSM) every 4 hours.
- Website
- aa.com
Flights from Key West International Airport to Des Moines via Charlotte
- Ave. Duration
- 7h 54m
- When
- Every day
- Estimated price
- $200–900
Flights from Key West International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 8h 53m
- When
- Saturday
- Estimated price
- $200–900
Flights from Key West International Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 9h 52m
- When
- Every day
- Estimated price
- $210–950
Flights from Key West International Airport to Des Moines via Miami
- Ave. Duration
- 10h 39m
- When
- Saturday
- Estimated price
- $190–850
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Miami Amtrak Station to Chicago Union Station
- Ave. Duration
- 46h 40m
- Frequency
- Once daily
- Estimated price
- $550–1,300
- Website
- Amtrak
Train from Miami Amtrak Station to Newark Penn Station
- Ave. Duration
- 27h 25m
- Frequency
- Once daily
- Estimated price
- $360–850
- Website
- Amtrak
Train from Miami Amtrak Station to Chicago Union Station
- Ave. Duration
- 46h 40m
- Frequency
- Once daily
- Estimated price
- $550–1,300
- Website
- Amtrak
Train from Chicago Union Station to Galesburg Amtrak Station
- Ave. Duration
- 2h 36m
- Frequency
- 4 times a day
- Estimated price
- $40–100
- Website
- Amtrak
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- Key West Transit
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- Key West Transit
Want to know more about travelling around United States
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