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How to get fromKey West to Des Moinesby plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Find Transport to Des Moines

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There are 5 ways to get from Key West to Des Moines by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Key West International Airport (EYW) to Des Moines (DSM)plane plane EYW - DSM
    5h 39m
    $140–587

  2. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    2d 12h
    $435–679

  3. Bus, train

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Amtrak Station to Chicago Union Stationtrain train
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    2d 13h
    $1,203–1,952

  4. Drive  1,682.5 mi

    1. Drive from Key West to Des Moinescar car 1,682.5 mi
    30h 21m
    $307–444

  5. Shuttle, train, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the train from Miami Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    2d 14h
    $1,417–2,229

Key West to Des Moines by bus and foot

Calendar4Weekly Services
Duration2d 12hAverage Duration
Ticket$435Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West to Des Moines.ExpandLaunch map view
  • Distance: 1,366 mi
  • Duration: 5h 39m

What companies run services between Key West, FL, USA and Des Moines, IA, USA?

Delta, American Airlines, and United Airlines fly from Key West International Airport (EYW) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Des Moines via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Newark Penn Station, and Indianapolis Union Station in around 2d 12h.

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