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How to get fromKey West to Greenvilleby plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Greyhound)

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There are 7 ways to get from Key West to Greenville by plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP)plane plane EYW - GSP
    4h 18m
    $157–609

  2. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    24h 52m
    $184–416

  3. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Amtrak Station to Carytrain train
    4. Take the train from Cary to Charlotte Amtrak Stationtrain train
    5. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    36h 2m
    $455–989

  4. Drive 861.1 mi

    1. Drive from Key West to Greenvillecar car 861.1 mi
    16h 20m
    $158–227

  5. Fly to Asheville Regional Airport, taxi

    1. Fly from Key West International Airport (EYW) to Asheville Regional Airport (AVL)plane plane EYW - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    3h 11m
    $222–554

  6. Fly to Columbia, drive

    1. Fly from Key West International Airport (EYW) to Columbia (CAE)plane plane EYW - CAE
    2. Drive from Columbia-Airport-CAE to Greenvillecar car
    6h 51m
    $200–992

  7. Bus via Pembroke Pines

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Hollywood Sheridan Trirail Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    28h 19m
    $187–422

Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP) flights

Calendar45Weekly Planes
Duration4h 31mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Key West to Greenville.ExpandLaunch map view
  • Distance: 729.1 mi
  • Duration: 4h 18m

What companies run services between Key West, FL, USA and Greenville, SC, USA?

Breeze Airways, Delta, and American Airlines fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Greenville via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 24h 52m.

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