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How to get fromKey West to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Key West to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Key West International Airport (EYW) to Mcghee Tyson Airport (TYS)plane plane EYW - TYS
    2h 37m
    $197–784

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Asheville Regional Airport (AVL)plane plane EYW - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 27m
    $104–409

  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami to Washington Union Stationbus bus
    4. Take the bus from Washington Union Station to New York Midtownbus bus
    5. Take the bus from New York to Knoxvillebus bus Nyc
    47h 41m
    $428–678

  4. Bus, train via Farragut

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h 59m
    $673–1,270

  5. Drive 998.6 mi

    1. Drive from Key West to Knoxvillecar car 998.6 mi
    18h 11m
    $183–264

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Key West International Airport (EYW) to Chattanooga Metropolitan Airport (CHA)plane plane EYW - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 7m
    $160–742

  7. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d
    $628–1,180

Key West International Airport (EYW) to Mcghee Tyson Airport (TYS) flights

Calendar33Weekly Planes
Duration4h 43mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Key West to Knoxville.ExpandLaunch map view
  • Distance: 803.8 mi
  • Duration: 2h 37m

What companies run services between Key West, FL, USA and Knoxville, TN, USA?

Allegiant Air, Delta, and American Airlines fly from Key West International Airport (EYW) to Mcghee Tyson Airport (TYS) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Knoxville via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami, Airport Intermodal Station, Miami, Washington Union Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 47h 41m.

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