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How to get fromKey West to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, or bus

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There are 5 ways to get from Key West to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Key West International Airport (EYW) to Louisville International Airport (SDF)plane plane EYW - SDF
    5h 16m
    $143–667

  2. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    5. Take the bus from Nashville to Louisville, KYbus bus
    29h 32m
    $186–354

  3. Drive 1,176 mi

    1. Drive from Key West to Louisvillecar car 1,176 mi
    22h 7m
    $215–310

  4. Fly to Blue Grass Airport, drive

    1. Fly from Key West International Airport (EYW) to Blue Grass Airport (LEX)plane plane EYW - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 56m
    $205–983

  5. Fly to Covington, bus

    1. Fly from Key West International Airport (EYW) to Covington (CVG)plane plane EYW - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    6h 34m
    $163–761

Key West to Louisville by bus and foot

Calendar14Weekly Services
Duration29h 32mAverage Duration
Ticket$186Cheapest Price
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Questions & Answers

Map of how to get from Key West to Louisville.ExpandLaunch map view
  • Distance: 978.8 mi
  • Duration: 5h 16m

What companies run services between Key West, FL, USA and Louisville, KY, USA?

Allegiant Air, Delta, and American Airlines fly from Key West International Airport (EYW) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Louisville, KY via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, and Nashville in around 29h 32m.

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