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How to get fromKey West to Mississippiby plane, bus (Greyhound, Flixbus), car, shuttle, or bus

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There are 7 ways to get from Key West to Mississippi by plane, bus (Greyhound, Flixbus), car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gulfport-Biloxi Regional Airport

    best
    1. Fly from Key West International Airport (EYW) to Gulfport-Biloxi Regional Airport (GPT)plane plane EYW - GPT
    4h 28m
    $133–628

  2. Fly to Golden Triangle Regional Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR)plane plane EYW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    5h 37m
    $108–461

  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Jacksonbus bus
    28h 17m
    $160–329

  4. Drive  1,043.8 mi

    1. Drive from Key West to Jacksoncar car 1,043.8 mi
    18h 53m
    $191–276

  5. Fly to Memphis

    1. Fly from Key West International Airport (EYW) to Memphis (MEM)plane plane EYW - MEM
    4h 31m
    $194–841

  6. Fly to Jackson/Vicksburg

    1. Fly from Key West International Airport (EYW) to Jackson/Vicksburg (JAN)plane plane EYW - JAN
    4h 36m
    $132–484

  7. Shuttle, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Baton Rouge Bus Stationbus bus
    4. Take the bus from Baton Rouge Bus Station to Jacksonbus bus
    34h 1m
    $389–641

Key West to Mississippi by bus and foot

Calendar14Weekly Services
Duration28h 17mAverage Duration
Ticket$160Cheapest Price
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Questions & Answers

Map of how to get from Key West to Mississippi.ExpandLaunch map view
  • Distance: 609.3 mi
  • Duration: 4h 28m

What companies run services between Key West, FL, USA and Mississippi, USA?

Delta, American Airlines, and Breeze Airways fly from Key West International Airport (EYW) to Gulfport-Biloxi Regional Airport (GPT) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Jackson via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 28h 17m.

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