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How to get fromKey West to Murrells Inletby plane, bus, train, car, bus (Greyhound, Flixbus), or shuttle

Find Transport to Murrells Inlet

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There are 6 ways to get from Key West to Murrells Inlet by plane, bus, train, car, bus (Greyhound, Flixbus), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Myrtle Beach

    best
    1. Fly from Key West International Airport (EYW) to Myrtle Beach (MYR)plane plane EYW - MYR
    4h 32m
    $127–434

  2. Fly to Florence Regional Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Florence Regional Airport (FLO)plane plane EYW - FLO
    2. Drive from Florence Regional Airport (FLO) to Murrells Inletcar car
    6h 20m
    $105–454

  3. Bus, train, drive

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Kingstree Stationtrain train
    4. Drive from Kingstree Station to Murrells Inletcar car
    23h 3m
    $224–482

  4. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Fayetteville Bus Stationbus bus
    4. Take the bus from Fayetteville Bus Station to Wilmington Cape Fear Public Transitbus bus
    5. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    28h 14m
    $186–330

  5. Drive 820.6 mi

    1. Drive from Key West to Murrells Inletcar car 820.6 mi
    15h 1m
    $150–217

  6. Shuttle, train, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the train from Miami Amtrak Station to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    24h 2m
    $396–691

Key West International Airport (EYW) to Myrtle Beach (MYR) flights

Calendar34Weekly Planes
Duration4h 56mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Key West to Murrells Inlet.ExpandLaunch map view
  • Distance: 668.6 mi
  • Duration: 4h 32m

What companies run services between Key West, FL, USA and Murrells Inlet, SC, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Myrtle Beach (MYR) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Murrells Inlet via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Fayetteville Bus Station, Wilmington Cape Fear Public Transit, and Myrtle Beach Bus Station in around 28h 14m.

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