Rome2Rio

How to get fromKey West to Murrells Inletby plane, bus, train, car, bus (Greyhound, Flixbus), or shuttle

Find Transport to Murrells Inlet

See all options

There are 6 ways to get from Key West to Murrells Inlet by plane, bus, train, car, bus (Greyhound, Flixbus), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Myrtle Beach

    best
    1. Fly from Key West International Airport (EYW) to Myrtle Beach (MYR)plane plane EYW - MYR
    4h 39m
    $127–464

  2. Bus, train, drive

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Kingstree Stationtrain train
    4. Drive from Kingstree Station to Murrells Inletcar car
    23h 3m
    $419–662

  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Fayetteville Bus Stationbus bus
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    26h 19m
    $212–329

  4. Drive  820.6 mi

    1. Drive from Key West to Murrells Inletcar car 820.6 mi
    15h 1m
    $150–217

  5. Fly to Wilmington International Airport, bus

    1. Fly from Key West International Airport (EYW) to Wilmington International Airport (ILM)plane plane EYW - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    7h 12m
    $169–658

  6. Shuttle, train, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the train from Miami Amtrak Station to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    24h 12m
    $590–890

Key West International Airport (EYW) to Myrtle Beach (MYR) flights

Calendar20Weekly Planes
Duration4h 42mAverage Duration
Ticket$77Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Key West to Murrells Inlet.ExpandLaunch map view
  • Distance: 668.6 mi
  • Duration: 4h 39m

What companies run services between Key West, FL, USA and Murrells Inlet, SC, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Myrtle Beach (MYR) 3 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Murrells Inlet via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Fayetteville Bus Station, and Myrtle Beach Bus Station in around 26h 19m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There