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How to get fromKey West to Panama Cityby plane, car, or shuttle

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There are 4 ways to get from Key West to Panama City by plane, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Tocumen International Airport

    best
    1. Fly from Key West International Airport (EYW) to Tocumen International Airport (PTY)plane plane EYW - PTY
    6h 13m
    $150–502

  2. Drive 6,440.3 km

    1. Drive from Key West to Panama Citycar car 6,440.3 km
    3d 11h
    $881–1,273

  3. Fly Key West International Airport to Panama Pacific International Airport

    1. Fly from Key West International Airport (EYW) to Panama Pacific International Airport (BLB)plane plane EYW - BLB
    17h 18m
    $179–365

  4. Shuttle to Miami International Airport, fly to Tocumen International Airport

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Tocumen International Airport (PTY)plane plane MIA - PTY
    11h 5m
    $430–682

Key West International Airport (EYW) to Tocumen International Airport (PTY) flights

Calendar36Weekly Planes
Duration6h 24mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Key West to Panama City.ExpandLaunch map view
  • Distance: 1,767.9 km
  • Duration: 6h 13m

What companies run services between Key West, FL, USA and Panama City, Panama?

Delta, American Airlines, and two other airlines fly from Key West International Airport (EYW) to Tocumen International Airport (PTY) 5 times a day.

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