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How to get fromKey West to Panama Cityby plane, car, or shuttle

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There are 5 ways to get from Key West to Panama City by plane, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Tocumen International Airport

    best
    1. Fly from Key West International Airport (EYW) to Tocumen International Airport (PTY)plane plane EYW - PTY
    6h 4m
    $150–532

  2. Drive  6,440.4 km

    1. Drive from Key West to Panama Citycar car 6,440.4 km
    3d 11h
    $881–1,273

  3. Shuttle to Miami International Airport, fly to Tocumen International Airport

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Tocumen International Airport (PTY)plane plane MIA - PTY
    11h 5m
    $295–652

  4. Fly Key West International Airport to Panama Pacific International Airport

    1. Fly from Key West International Airport (EYW) to Panama Pacific International Airport (BLB)plane plane EYW - BLB
    18h 46m
    $249–515

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Tocumen International Airport

    1. Take a shuttle bus from Key West, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Tocumen International Airport (PTY)plane plane FLL - PTY
    11h 36m
    $330–742

Key West International Airport (EYW) to Tocumen International Airport (PTY) flights

Calendar17Weekly Planes
Duration6h 36mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West to Panama City.ExpandLaunch map view
  • Distance: 1,767.9 km
  • Duration: 6h 4m

What companies run services between Key West, FL, USA and Panama City, Panama?

American Airlines, Copa Airlines, and two other airlines fly from Key West International Airport (EYW) to Tocumen International Airport (PTY) twice daily.

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