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How to get fromKey West to Panama City Beachby plane, shuttle, bus, car, train, or bus (Greyhound, Flixbus)

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There are 10 ways to get from Key West to Panama City Beach by plane, shuttle, bus, car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP)plane plane EYW - ECP
    4h 35m
    $142–469

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Destin–Fort Walton Beach Airport (VPS)plane plane EYW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 57m
    $87–370

  3. Shuttle, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    19h 20m
    $319–493

  4. Drive 707.2 mi

    1. Drive from Key West to Panama City Beachcar car 707.2 mi
    14h 2m
    $130–187

  5. Fly to Dothan Regional Airport, drive

    1. Fly from Key West International Airport (EYW) to Dothan Regional Airport (DHN)plane plane EYW - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    6h 22m
    $104–410

  6. Fly to Tallahassee, bus

    1. Fly from Key West International Airport (EYW) to Tallahassee (TLH)plane plane EYW - TLH
    2. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    6h 55m
    $130–479

  7. Fly to Pensacola International Airport, bus

    1. Fly from Key West International Airport (EYW) to Pensacola International Airport (PNS)plane plane EYW - PNS
    2. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    7h 23m
    $96–366

  8. Bus, train

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Tallahasseebus bus
    5. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    20h 6m
    $126–227

  9. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h 41m
    $132–261

  10. Bus, train via Jacksonville

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Amtrak Station to Jacksonvilletrain train
    4. Take the bus from Jacksonville to Tallahasseebus bus
    5. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h 45m
    $222–437

Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar38Weekly Planes
Duration5h 34mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Key West to Panama City Beach.ExpandLaunch map view
  • Distance: 492.2 mi
  • Duration: 4h 35m

What companies run services between Key West, FL, USA and Panama City Beach, FL, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Panama City Beach via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Tallahassee, and Panama City Beach Bus Station in around 23h 41m.

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