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How to get fromKey West to Panama Cityby plane or car

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There are 6 ways to get from Key West to Panama City by plane or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP)plane plane EYW - ECP
    4h 41m
    $157–494

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Destin–Fort Walton Beach Airport (VPS)plane plane EYW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    6h 9m
    $89–382

  3. Drive 699.7 mi

    1. Drive from Key West to Panama Citycar car 699.7 mi
    13h 51m
    $128–185

  4. Fly to Tallahassee, drive

    1. Fly from Key West International Airport (EYW) to Tallahassee (TLH)plane plane EYW - TLH
    2. Drive from Tallahassee (TLH) to Panama Citycar car
    5h 33m
    $104–460

  5. Fly to Dothan Regional Airport, drive

    1. Fly from Key West International Airport (EYW) to Dothan Regional Airport (DHN)plane plane EYW - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    6h 6m
    $103–428

  6. Fly to Pensacola International Airport, drive

    1. Fly from Key West International Airport (EYW) to Pensacola International Airport (PNS)plane plane EYW - PNS
    2. Drive from Pensacola-Airport-PNS to Panama Citycar car
    6h 29m
    $301–743

Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar38Weekly Planes
Duration5h 34mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Key West to Panama City.ExpandLaunch map view
  • Distance: 496.4 mi
  • Duration: 4h 41m

What companies run services between Key West, FL, USA and Panama City, FL, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) 5 times a day.

Airlines

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