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How to get fromKey West to Port Saint Lucieby plane, bus, bus (Greyhound), car, or shuttle

Find Transport to Port Saint Lucie

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There are 8 ways to get from Key West to Port Saint Lucie by plane, bus, bus (Greyhound), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Miami International Airport, bus

    best
    1. Fly from Key West International Airport (EYW) to Miami International Airport (MIA)plane plane EYW - MIA
    2. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    4h 54m
    $80–360

  2. Drive  272.3 mi

    cheapest
    1. Drive from Key West to Port Saint Luciecar car 272.3 mi
    5h 23m
    $50–72

  3. Bus via Pembroke Pines

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    9h 24m
    $56–85

  4. Fly to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    3h 46m
    $86–379

  5. Fly to Orlando, bus

    1. Fly from Key West International Airport (EYW) to Orlando (MCO)plane plane EYW - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    5h 54m
    $111–708

  6. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Key West International Airport (EYW) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane EYW - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 27m
    $262–609

  7. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami International Airport to Fort Piercebus bus
    10h 13m
    $53–79

  8. Shuttle, bus

    1. Take a shuttle bus from Plaza Hotel to Bayside Marketplaceshuttle bus
    2. Take the bus from Miami Beach to Port St Luciebus bus FlixBus N2411
    11h 8m
    $83–95

Key West to Port Saint Lucie by bus, foot, and train

Calendar14Weekly Services
Duration9h 24mAverage Duration
Ticket$56Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Key West to Port Saint Lucie.ExpandLaunch map view
  • Distance: 245.4 mi
  • Duration: 4h 54m

What companies run services between Key West, FL, USA and Port Saint Lucie, FL, USA?

You can take a bus from N Roosevelt & 3rd Street to Fort Pierce via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami, Airport Intermodal Station, Miami Airport Station, Sheridan Street Station, and Sheridan Tri-Rail Station in around 9h 24m.

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