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How to get fromKey West to San Antonioby plane, ferry, bus, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Key West to San Antonio by plane, ferry, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Antonio International Airport

    best
    1. Fly from Key West International Airport (EYW) to San Antonio International Airport (SAT)plane plane EYW - SAT
    5h 52m
    $154–666

  2. Ferry, bus

    1. Take the ferry from Key West, FL to Marco Island, FLferry ferry
    2. Take the bus from Naples to Tallahassee FSUbus bus
    3. Take the bus from Tallahassee to Houston Bus Stationbus bus
    4. Take the bus from Houston Bus Station to San Antonio Bus Stationbus bus
    35h 56m
    $422–677

  3. Drive 1,519.1 mi

    1. Drive from Key West to San Antoniocar car 1,519.1 mi
    26h 13m
    $278–401

  4. Fly to Austin-Bergstrom International Airport, bus

    1. Fly from Key West International Airport (EYW) to Austin-Bergstrom International Airport (AUS)plane plane EYW - AUS
    2. Take the bus from Austin Eastside Bus Plaza to San Antonio Bus Stationbus bus
    8h 24m
    $166–692

  5. Ferry, bus, drive

    1. Take the ferry from Key West, FL to Fort Myers Beach, FLferry ferry
    2. Take the bus from Fort Myers to Clewistonbus bus
    3. Drive from Clewiston to Port St Luciecar car
    4. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    5. Take the bus from Atlanta Bus Station to Houston Bus Stationbus bus
    6. Take the bus from Hyatt Regency Galleria Houston to San Antoniobus bus
    41h 31m
    $576–809

  6. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Houston Bus Stationbus bus
    5. Take the bus from Houston Bus Station to San Antonio Bus Stationbus bus
    41h 47m
    $247–494

Key West to San Antonio by bus and foot

Calendar14Weekly Services
Duration41h 47mAverage Duration
Ticket$247Cheapest Price
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Questions & Answers

Map of how to get from Key West to San Antonio.ExpandLaunch map view
  • Distance: 1,094.3 mi
  • Duration: 5h 52m

What companies run services between Key West, FL, USA and San Antonio, TX, USA?

American Airlines, Delta, and United Airlines fly from Key West International Airport (EYW) to San Antonio International Airport (SAT) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to San Antonio Bus Station via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Tallahassee, and Houston Bus Station in around 41h 47m.

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