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How to get fromKey West to Sanfordby plane, train, shuttle, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Key West to Sanford by plane, train, shuttle, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Orlando, train

    best
    1. Fly from Key West International Airport (EYW) to Orlando (MCO)plane plane EYW - MCO
    2. Take the train from Sand Lake Road to Sanfordtrain train
    3h 33m
    $87–671

  2. Fly to Orlando Sanford

    cheapest
    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    1h 19m
    $57–304

  3. Shuttle, bus, train

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Orlando - RedCoach Station, FLbus bus
    3. Take the train from Sand Lake Road to Sanfordtrain train
    12h 24m
    $232–331

  4. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami to Orlandotrain train
    4. Take the train from Sand Lake Road to Sanfordtrain train
    12h 31m
    $88–248

  5. Drive 388.6 mi

    1. Drive from Key West to Sanfordcar car 388.6 mi
    8h 11m
    $71–103

  6. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Orlandobus bus
    13h 28m
    $60–110

  7. Bus, train via Pembroke Pines

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Winter Park Amtrak Stationtrain train
    14h 16m
    $106–224

Key West to Sanford by bus, shuttle, and train

Calendar21Weekly Services
Duration12h 24mAverage Duration
Ticket$232Cheapest Price
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Questions & Answers

Map of how to get from Key West to Sanford.ExpandLaunch map view
  • Distance: 305.8 mi
  • Duration: 3h 33m

What companies run services between Key West, FL, USA and Sanford, FL, USA?

Allegiant Air flies from Key West International Airport (EYW) to Orlando Sanford (SFB) twice a week. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Sanford via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Orlando, Florida Mall, N Garland Ave & W Amelia St, New York Ave & Welbourne Ave, and Winter Park in around 13h 28m.

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