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How to get fromKey West to South Carolinaby plane, taxi, bus, train, or car

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There are 8 ways to get from Key West to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT)plane plane EYW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 4m
    $192–664

  2. Drive 740.7 mi

    cheapest
    1. Drive from Key West to Charlestoncar car 740.7 mi
    13h 15m
    $136–196

  3. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train
    20h 44m
    $265–520

  4. Bus, taxi

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Savannah Bus Stationbus bus
    5. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    6. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    24h 21m

  5. Fly to Greenville–Spartanburg International Airport

    1. Fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP)plane plane EYW - GSP
    4h 18m
    $157–609

  6. Fly to Asheville Regional Airport, taxi

    1. Fly from Key West International Airport (EYW) to Asheville Regional Airport (AVL)plane plane EYW - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    3h 11m
    $222–544

  7. Fly to Charleston International Airport

    1. Fly from Key West International Airport (EYW) to Charleston International Airport (CHS)plane plane EYW - CHS
    5h 3m
    $284–516

  8. Fly to Columbia

    1. Fly from Key West International Airport (EYW) to Columbia (CAE)plane plane EYW - CAE
    6h 24m
    $174–866

Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT) flights

Calendar49Weekly Planes
Duration4h 4mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Key West to South Carolina.ExpandLaunch map view
  • Distance: 768.7 mi
  • Duration: 3h 4m

What companies run services between Key West, FL, USA and South Carolina, USA?

Breeze Airways, Delta, and American Airlines fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP) every 4 hours.

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