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How to get fromKey West to South Carolinaby plane, taxi, bus, train, or car

Find Transport to South Carolina

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There are 8 ways to get from Key West to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT)plane plane EYW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 1m
    $202–764

  2. Fly to Columbia

    cheapest
    1. Fly from Key West International Airport (EYW) to Columbia (CAE)plane plane EYW - CAE
    5h 53m
    $89–426

  3. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train
    20h 44m
    $407–635

  4. Drive  740.7 mi

    1. Drive from Key West to Charlestoncar car 740.7 mi
    13h 15m
    $136–196

  5. Fly to Greenville–Spartanburg International Airport

    1. Fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP)plane plane EYW - GSP
    4h 33m
    $157–709

  6. Fly to Asheville Regional Airport, taxi

    1. Fly from Key West International Airport (EYW) to Asheville Regional Airport (AVL)plane plane EYW - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    3h 14m
    $227–604

  7. Fly to Charleston International Airport

    1. Fly from Key West International Airport (EYW) to Charleston International Airport (CHS)plane plane EYW - CHS
    5h 4m
    $99–496

  8. Fly to Florence Regional Airport

    1. Fly from Key West International Airport (EYW) to Florence Regional Airport (FLO)plane plane EYW - FLO
    6h 41m
    $102–467

Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT) flights

Calendar49Weekly Planes
Duration3h 51mAverage Duration
Ticket$114Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West to South Carolina.ExpandLaunch map view
  • Distance: 768.7 mi
  • Duration: 3h 1m

What companies run services between Key West, FL, USA and South Carolina, USA?

Delta, American Airlines, and Breeze Airways fly from Key West International Airport (EYW) to Greenville–Spartanburg International Airport (GSP) every 4 hours.

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