Rome2Rio

How to get fromKirksville to Knoxvilleby plane, train, bus, car, shuttle, or taxi

Find Transport to Knoxville

See all options

There are 9 ways to get from Kirksville to Knoxville by plane, train, bus, car, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Kirksville Regional Airport to Mcghee Tyson Airport

    best
    1. Fly from Kirksville Regional Airport (IRK) to Mcghee Tyson Airport (TYS)plane plane IRK - TYS
    5h 37m
    $221–813

  2. Drive 675.1 mi

    cheapest
    1. Drive from Kirksville to Knoxvillecar car 675.1 mi
    12h 7m
    $124–178

  3. Train, bus

    1. Take the train from La Plata Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    40h 39m
    $619–1,158

  4. Train, bus via Indianapolis

    1. Take the train from La Plata Station to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    43h 10m
    $424–703

  5. Train to Kansas City, fly to Mcghee Tyson Airport

    1. Take the train from La Plata Station to Kansas Citytrain train
    2. Fly from Kansas City (MCI) to Mcghee Tyson Airport (TYS)plane plane MCI - TYS
    9h 26m
    $311–1,120

  6. Drive to Burlington Municipal Airport, fly to Mcghee Tyson Airport

    1. Drive from Kirksville to Burlington Municipal Airport (BRL)car car
    2. Fly from Burlington Municipal Airport (BRL) to Mcghee Tyson Airport (TYS)plane plane BRL - TYS
    7h 14m
    $196–801

  7. Shuttle, taxi to Quincy Regional Airport, fly to Nashville, drive

    1. Take a shuttle bus from Hy-Vee - Kirksville to Moberlyshuttle bus
    2. Take a shuttle bus from Moberly to Hannibalshuttle bus
    3. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    4. Fly from Quincy Regional Airport (UIN) to Nashville (BNA)plane plane UIN - BNA
    5. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 55m
    $236–629

  8. Train, bus via Ossining

    1. Take the train from La Plata Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    41h 9m
    $574–1,085

  9. Train, bus #2

    1. Take the train from La Plata Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 49m
    $385–630

Kirksville Regional Airport (IRK) to Mcghee Tyson Airport (TYS) flights

Calendar26Weekly Planes
Duration6h 43mAverage Duration
Ticket$139Cheapest Price
See schedules

Questions & Answers

Map of how to get from Kirksville to Knoxville.ExpandLaunch map view
  • Distance: 572.6 mi
  • Duration: 5h 37m

What companies run services between Kirksville, MO, USA and Knoxville, TN, USA?

Corporate Flight Management Inc, American Airlines, and United Airlines fly from Kirksville Regional Airport (IRK) to Mcghee Tyson Airport (TYS) 4 times a day.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound