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How to get fromKirksville to Louisvilleby plane, car, train, or bus

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There are 8 ways to get from Kirksville to Louisville by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Kirksville Regional Airport to Blue Grass Airport, drive

    best
    1. Fly from Kirksville Regional Airport (IRK) to Blue Grass Airport (LEX)plane plane IRK - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 52m
    $189–862

  2. Drive 463.9 mi

    cheapest
    1. Drive from Kirksville to Louisvillecar car 463.9 mi
    7h 59m
    $85–123

  3. Train, bus

    1. Take the train from La Plata Station to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    12h 8m
    $143–265

  4. Train, bus via Chicago (Amtrak)

    1. Take the train from La Plata Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 13m
    $223–430

  5. Fly Kirksville Regional Airport to Louisville International Airport

    1. Fly from Kirksville Regional Airport (IRK) to Louisville International Airport (SDF)plane plane IRK - SDF
    6h 10m
    $132–596

  6. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from La Plata Station to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    10h 8m
    $227–816

  7. Drive to Burlington Municipal Airport, fly to Louisville International Airport

    1. Drive from Kirksville to Burlington Municipal Airport (BRL)car car
    2. Fly from Burlington Municipal Airport (BRL) to Louisville International Airport (SDF)plane plane BRL - SDF
    8h 41m
    $107–524

  8. Fly Kirksville Regional Airport to Covington, bus

    1. Fly from Kirksville Regional Airport (IRK) to Covington (CVG)plane plane IRK - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    9h 47m
    $287–990

Kirksville Regional Airport (IRK) to Blue Grass Airport (LEX) flights

Calendar28Weekly Planes
Duration6h 33mAverage Duration
Ticket$143Cheapest Price
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Questions & Answers

Map of how to get from Kirksville to Louisville.ExpandLaunch map view
  • Distance: 528.6 mi
  • Duration: 5h 52m

What companies run services between Kirksville, MO, USA and Louisville, KY, USA?

Corporate Flight Management Inc, American Airlines, and United Airlines fly from Kirksville Regional Airport (IRK) to Louisville International Airport (SDF) once daily.

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