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How to get fromKirksville to St. Louisby train, bus, train (Amtrak), car, or shuttle

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There are 4 ways to get from Kirksville to St. Louis by train, bus, train (Amtrak), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from La Plata Station to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    8h 54m

  2. Drive  205.6 mi

    cheapest
    1. Drive from Kirksville to St. Louiscar car 205.6 mi
    3h 45m
    $36–51

  3. Train (Amtrak)

    1. Take the train from La Plata Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    9h 27m
    $265–407

  4. Shuttle

    1. Take a shuttle bus from Hy-Vee - Kirksville to Columbiashuttle bus
    2. Take a shuttle bus from Columbia to Bowling Green, Moshuttle bus
    3. Take a shuttle bus from Bowling Green, Mo to St. Louisshuttle bus
    6h 16m
    $37–49

Comparing Your Travel Options

Map of how to get from Kirksville to St. Louis.ExpandLaunch map view
  • Distance: 364.7 mi
  • Duration: 8h 54m

What companies run services between Kirksville, MO, USA and St. Louis, MO, USA?

You can take a vehicle from Kirksville to St. Louis via La Plata Station and Kansas City in around 9h 27m. Alternatively, you can take a shuttle from Hy-Vee - Kirksville to St. Louis via Columbia, Bowling Green, Mo, and St. Louis in around 6h 16m.

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