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How to get fromKissimmee to Greenvilleby plane, bus (Flixbus, Greyhound), train, bus, car, taxi, bus (Flixbus), or bus (Greyhound)

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There are 11 ways to get from Kissimmee to Greenville by plane, bus (Flixbus, Greyhound), train, bus, car, taxi, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Greenville–Spartanburg International Airport

    best
    1. Fly from Orlando (MCO) to Greenville–Spartanburg International Airport (GSP)plane plane MCO - GSP
    3h 45m
    $179–750

  2. Drive 515.3 mi

    cheapest
    1. Drive from Kissimmee to Greenvillecar car 515.3 mi
    9h 58m
    $94–136

  3. Bus via LYNX Central

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    14h 36m
    $133–307

  4. Train, bus

    1. Take the train from Kissimmee Amtrak Station to Carytrain train
    2. Take the train from Cary to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    22h 16m
    $311–696

  5. Taxi to Orlando Sanford, fly to Asheville Regional Airport, taxi

    1. Take the taxi from Kissimmee to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    3h 36m
    $302–636

  6. Fly Orlando to Asheville Regional Airport, taxi

    1. Fly from Orlando (MCO) to Asheville Regional Airport (AVL)plane plane MCO - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 34m
    $199–485

  7. Train to Tampa, fly to Greenville–Spartanburg International Airport

    1. Take the train from Kissimmee Amtrak Station to Tampatrain train
    2. Fly from Tampa (TPA) to Greenville–Spartanburg International Airport (GSP)plane plane TPA - GSP
    6h
    $155–431

  8. Taxi to Orlando Sanford, fly to Greenville–Spartanburg International Airport

    1. Take the taxi from Kissimmee to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to Greenville–Spartanburg International Airport (GSP)plane plane SFB - GSP
    2h 45m
    $222–661

  9. Bus

    1. Take the bus from Orlando to Atlanta Bus Stationbus bus FlixBus 2415
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    16h 16m
    $135–294

  10. Bus #2

    1. Take the bus from Orlando Bus Station to Charlotte Bus Stationbus bus FlixBus 2433
    2. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus Charlotte
    17h 15m
    $140–310

  11. Bus via Gainesville

    1. Take the bus from N Main St & E Orange St to N Garland Ave & W Amelia Stbus bus 18
    2. Take the bus from Orlando Bus Station to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    19h 29m
    $132–309

Orlando (MCO) to Greenville–Spartanburg International Airport (GSP) flights

Calendar76Weekly Planes
Duration3h 53mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Kissimmee to Greenville.ExpandLaunch map view
  • Distance: 490.3 mi
  • Duration: 3h 45m

What companies run services between Kissimmee, FL, USA and Greenville, SC, USA?

Breeze Airways, Delta, and two other airlines fly from Orlando (MCO) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a train from Kissimmee to Greenville via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 14h 36m.

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