There are 4 ways to get from Kissimmee to Mayo Clinic Florida by train (Amtrak), bus (Flixbus), car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Kissimmee Amtrak Station to Jacksonvilletrain Silver Meteor / ...
4h 27m$108–178Drive 154.1 mi
cheapest- Drive from Kissimmee to Mayo Clinic Floridacar 154.1 mi
2h 43m$29–41Bus
- Take the bus from N Main St & E Orange St to N Garland Ave & W Amelia Stbus 18
- Take the bus from Orlando Bus Station to Jacksonvillebus FlixBus 2433 / ...
7h 14m$32–54Fly, taxi
- Fly from Orlando (MCO) to Jacksonville (JAX)plane MCO - JAX
- Take the taxi from Jacksonville-Airport-JAX to Mayo Clinic Floridataxi
5h 53m$414–745
Orlando (MCO) to Jacksonville (JAX) flights
Questions & Answers
The cheapest way to get from Kissimmee to Mayo Clinic Florida is to drive which costs $28 - $45 and takes 2h 43m.
The fastest way to get from Kissimmee to Mayo Clinic Florida is to drive which takes 2h 43m and costs $28 - $45.
No, there is no direct bus from Kissimmee to Mayo Clinic Florida. However, there are services departing from N Main St & E Orange St and arriving at 13924 Beach Blvd via N Garland Ave & W Amelia St, Orlando Bus Station and JRTC Bay M. The journey, including transfers, takes approximately 7h 14m.
No, there is no direct train from Kissimmee station to Mayo Clinic Florida. However, there are services departing from Kissimmee Amtrak Station and arriving at Jacksonville via . The journey, including transfers, takes approximately 4h 27m.
The distance between Kissimmee and Mayo Clinic Florida is 187 miles. The road distance is 155 miles.
The best way to get from Kissimmee to Mayo Clinic Florida without a car is to train which takes 4h 27m and costs $100 - $180.
It takes approximately 4h 27m to get from Kissimmee to Mayo Clinic Florida, including transfers.
Kissimmee to Mayo Clinic Florida bus services, operated by Lynx Central Florida Transport, depart from N Main St & E Orange St station.
Kissimmee to Mayo Clinic Florida train services, operated by Amtrak, depart from Kissimmee Amtrak Station.
The best way to get from Kissimmee to Mayo Clinic Florida is to train which takes 4h 27m and costs $100 - $180. Alternatively, you can bus, which costs $30 - $55 and takes 7h 14m.
What companies run services between Kissimmee, FL, USA and Mayo Clinic Florida, FL, USA?
Amtrak operates a train from Kissimmee Amtrak Station to Jacksonville twice daily. Tickets cost $50–110 and the journey takes 3h 54m. Alternatively, you can take a bus from N Main St & E Orange St to Mayo Clinic Florida via N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, Jacksonville, JRTC Bay M, and 13924 Beach Blvd in around 7h 14m.
- Website
- delta.com
Flights from Orlando to Jacksonville via Atlanta
- Ave. Duration
- 4h 19m
- When
- Every day
- Estimated price
- $75–390
- Website
- aa.com
Flights from Orlando to Jacksonville via Miami
- Ave. Duration
- 3h 39m
- When
- Wednesday, Thursday, Friday, Saturday, Sunday, and Monday
- Estimated price
- $65–360
Flights from Orlando to Jacksonville via Charlotte
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $80–420
- Website
- southwest.com
Flights from Orlando to Jacksonville via Nashville
- Ave. Duration
- 4h 55m
- When
- Sunday, Saturday, Monday, Thursday, and Friday
- Estimated price
- $100–480
- Website
- jetblue.com
Flights from Orlando to Jacksonville via Fort Lauderdale
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $60–360
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kissimmee Amtrak Station to Jacksonville
- Ave. Duration
- 3h 54m
- Frequency
- Twice daily
- Estimated price
- $50–110
- Website
- Amtrak
- Phone
- +1 407-841-5969
- [email protected]
- Website
- Lynx
Bus from N Main St & E Orange St to N Garland Ave & W Amelia St
- Ave. Duration
- 1h 35m
- Frequency
- Hourly
- Estimated price
- $2
- Website
- Lynx
- Schedules at
- Lynx Routes and Schedules
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Orlando Bus Station to Jacksonville
- Ave. Duration
- 2h 40m
- Frequency
- Every 2 hours
- Estimated price
- $22–40
- Schedules at
- Flixbus USA
- Ave. Duration
- 33 min
- Estimated price
- $70–90
ABC Taxi
- Phone
- +1 904-554-5564
- Website
- abctaxijax.com
zTrip
- Phone
- +1 904-222-2222
- Website
- ztrip.com
Want to know more about travelling around United States
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More Questions & Answers
Kissimmee to Mayo Clinic Florida bus services, operated by Lynx Central Florida Transport, arrive at N Garland Ave & W Amelia St station.
Kissimmee to Mayo Clinic Florida train services, operated by Amtrak, arrive at Jacksonville station.
Yes, the driving distance between Kissimmee to Mayo Clinic Florida is 155 miles. It takes approximately 2h 43m to drive from Kissimmee to Mayo Clinic Florida.
There are 477+ hotels available in Mayo Clinic Florida.