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How to get fromKnoxville Airport (TYS) to Chicagoby plane, bus, taxi, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Knoxville Airport (TYS) to Chicago by plane, bus, taxi, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2h 41m
    $73–406

  2. Bus, taxi, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the taxi from Mt. Juliet Station to Shell Gas Station - Exit 6taxi taxi
    3. Take the bus from Shell Gas Station - Exit 6 to Indianapolisbus bus
    4. Take the train from Indianapolis to Chicago Union Stationtrain train
    18h 53m
    $404–671

  3. Drive 539.6 mi

    1. Drive from Knoxville Airport (TYS) to Chicagocar car 539.6 mi
    9h 29m
    $99–143

  4. Fly to Chicago Midway International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2h 15m
    $85–472

  5. Bus via Jackson

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Chicagobus bus
    19h 37m
    $290–551

  6. Bus

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Chicago Bus Stationbus bus Greyhound US0125
    20h 47m
    $236–359

Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) flights

Calendar87Weekly Planes
Duration3h 13mAverage Duration
Ticket$71Cheapest Price
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Questions & Answers

Map of how to get from Knoxville Airport (TYS) to Chicago.ExpandLaunch map view
  • Distance: 493.2 mi
  • Duration: 2h 41m

What companies run services between Knoxville Airport (TYS), USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Knoxville Airport (TYS) to Harrison via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, California & 35th Street, Sox-35th Red Line Station, and Sox-35th in around 19h 37m.

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