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How to get fromKnoxville Airport (TYS) to Florida Keysby plane, bus (Flixbus, Greyhound), bus, train, car, or shuttle

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There are 6 ways to get from Knoxville Airport (TYS) to Florida Keys by plane, bus (Flixbus, Greyhound), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    5h 2m
    $175–575

  2. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York City Chinatown to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    47h 12m
    $399–604

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d
    $647–1,213

  4. Drive 961.1 mi

    1. Drive from Knoxville Airport (TYS) to Florida Keyscar car 961.1 mi
    18h 1m
    $176–254

  5. Fly to Miami International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane plane TYS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 42m
    $262–739

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 2m
    $285–776

Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) flights

Calendar27Weekly Planes
Duration4h 33mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Knoxville Airport (TYS) to Florida Keys.ExpandLaunch map view
  • Distance: 810 mi
  • Duration: 5h 2m

What companies run services between Knoxville Airport (TYS), USA and Florida Keys, FL, USA?

Allegiant Air, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a vehicle from Knoxville Airport (TYS) to Florida Keys via Knoxville, TN, New York City Chinatown, Orlando Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 47h 12m.

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