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How to get fromKnoxville Airport (TYS) to Key Westby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 4 ways to get from Knoxville Airport (TYS) to Key West by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    2h 16m
    $109–494

  2. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York City Chinatown to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    47h 58m
    $399–604

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 1h
    $647–1,213

  4. Drive 976.5 mi

    1. Drive from Knoxville Airport (TYS) to Key Westcar car 976.5 mi
    18h 24m
    $179–258

Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) flights

Calendar25Weekly Planes
Duration4h 37mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Knoxville Airport (TYS) to Key West.ExpandLaunch map view
  • Distance: 790.8 mi
  • Duration: 2h 16m

What companies run services between Knoxville Airport (TYS), USA and Key West, FL, USA?

Allegiant Air, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a vehicle from Knoxville Airport (TYS) to N Roosevelt & 3rd Street via Knoxville, TN, New York City Chinatown, Orlando Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 47h 58m.

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