There are 5 ways to get from Knoxville Airport (TYS) to St. Louis by plane, bus (Greyhound, Flixbus), rideshare, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Lambert–St. Louis International Airport
best- Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane TYS - STL
3h 53m$120–678Drive 483.7 mi
cheapest- Drive from Knoxville Airport (TYS) to St. Louiscar 483.7 mi
8h 3m$89–128Bus
- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to St Louis Bus Stationbus Greyhound US0186 / ...
11h 39m$189–272Airport Transfer
- Take the rideshare from Knoxville-TYS to St. Louis483.7 mi
8h 3mFly to Midamerica St. Louis Airport
- Fly from Mcghee Tyson Airport (TYS) to Midamerica St. Louis Airport (BLV)plane TYS - BLV
8h 5m$199–780
Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Knoxville Airport (TYS) to St. Louis is to drive which costs $85 - $130 and takes 8h 3m.
The fastest way to get from Knoxville Airport (TYS) to St. Louis is to fly which takes 3h 53m and costs $120 - $700.
No, there is no direct bus from Knoxville Airport (TYS) to St. Louis station. However, there are services departing from Knoxville and arriving at St Louis Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 11h 39m.
The distance between Knoxville Airport (TYS) and St. Louis is 421 miles. The road distance is 486.5 miles.
The best way to get from Knoxville Airport (TYS) to St. Louis without a car is to bus which takes 11h 39m and costs $180 - $280.
It takes approximately 3h 53m to get from Knoxville Airport (TYS) to St. Louis, including transfers.
Knoxville Airport (TYS) to St. Louis bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville Airport (TYS) to St. Louis is to fly which takes 3h 53m and costs $120 - $700. Alternatively, you can bus, which costs $180 - $280 and takes 11h 39m.
Knoxville Airport (TYS) to St. Louis bus services, operated by Wanda Coach, arrive at Nashville station.
St. Louis is 1h behind Knoxville Airport (TYS). It is currently 1:03 PM in Knoxville Airport (TYS) and 12:03 PM in St. Louis.
What companies run services between Knoxville Airport (TYS), USA and St. Louis, MO, USA?
Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Knoxville Airport (TYS) to St Louis Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 11h 39m.
- Website
- delta.com
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $140–800
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $180–900
- Website
- aa.com
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $160–850
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $160–850
- Website
- united.com
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $160–850
- Website
- southwest.com
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 4h 13m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $110–700
- Website
- allegiantair.com
Flights from Mcghee Tyson Airport to Midamerica St. Louis Airport via Orlando Sanford
- Ave. Duration
- 9h 37m
- When
- Thursday and Sunday
- Estimated price
- $170–750
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Nashville Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- 4 times a day
- Estimated price
- $45–90
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- Once daily
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
- Website
- https://www.mozio.com
Rideshare from Knoxville-TYS to St. Louis
- Ave. Duration
- 8h 3m
- Frequency
- On demand
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More Questions & Answers
Yes, the driving distance between Knoxville Airport (TYS) to St. Louis is 487 miles. It takes approximately 8h 3m to drive from Knoxville Airport (TYS) to St. Louis.
There are 458+ hotels available in St. Louis.
Check out Blablacar's carpooling service for rideshare options between Knoxville Airport (TYS) and St. Louis. A great option if you don't have a driver's licence or want to avoid public transport.