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How to get fromKnoxville to St. Louisby bus, train, car, taxi, plane, or bus (Amtrak, Flixbus)

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There are 7 ways to get from Knoxville to St. Louis by bus, train, car, taxi, plane, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train (Amtrak)

    best
    1. Take the bus from Galesburg Amtrak Station to Springfieldbus bus Amtrak Thruway Connecting Service
    2. Take the train from Springfield to St. Louistrain train Lincoln Service / ...
    5h 11m
    $84–143

  2. Drive 178.9 mi

    cheapest
    1. Drive from Knoxville to St. Louiscar car 178.9 mi
    4h 28m
    $33–48

  3. Taxi to Quad City International Airport, fly

    1. Take the taxi from Knoxville to Moline-Airport-MLItaxi taxi
    2. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    5h 28m
    $215–625

  4. Bus

    1. Take the bus from Galesburg Amtrak Station to Springfieldbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus FlixBus N2521 / ...
    5h 25m
    $71–106

  5. Bus to Peoria International Airport, fly

    1. Take the bus from Galesburg Amtrak Station to Peoria Amtrak Stationbus bus
    2. Fly from Peoria International Airport (PIA) to Lambert–St. Louis International Airport (STL)plane plane PIA - STL
    7h 28m
    $113–509

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    6h 49m
    $152–694

  7. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    7h 4m
    $344–841

Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL) flights

Calendar103Weekly Planes
Duration5h 24mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to St. Louis.ExpandLaunch map view
  • Distance: 218.5 mi
  • Duration: 5h 11m

What companies run services between Knoxville, IL, USA and St. Louis, MO, USA?

You can take a vehicle from Knoxville to St Louis Bus Station via Galesburg Amtrak Station, Springfield, Washington & 4th, and Springfield SMTD Transfer Center in around 5h 25m.

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