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How to get fromKnoxville to Amherstby plane, bus, train, or car

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There are 4 ways to get from Knoxville to Amherst by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    4h 22m
    $230–945

  2. Drive 690.1 mi

    cheapest
    1. Drive from Knoxville to Amherstcar car 690.1 mi
    11h 41m
    $126–182

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    21h 56m
    $277–488

  4. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    26h 10m
    $277–524

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar96Weekly Planes
Duration5h 9mAverage Duration
Ticket$158Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Amherst.ExpandLaunch map view
  • Distance: 585.4 mi
  • Duration: 4h 22m

What companies run services between Knoxville, TN, USA and Amherst, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Knoxville to Main Street & University Station via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, El Mercadito Grocery - Clarksville, IN, Louisville, KY Bus Station, Cleveland, OH, Buffalo, NY, and North Division Street & Ellicott Street in around 26h 10m.

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