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How to get fromKnoxville to Biloxiby plane, bus (Greyhound, Flixbus), car, bus, or train

Find Transport to Biloxi

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There are 7 ways to get from Knoxville to Biloxi by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Gulfport-Biloxi Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Gulfport-Biloxi Regional Airport (GPT)plane plane TYS - GPT
    4h 13m
    $152–472

  2. Drive  555.5 mi

    cheapest
    1. Drive from Knoxville to Biloxicar car 555.5 mi
    9h 39m
    $102–147

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to La Grange Bus Stationbus bus
    4. Take the bus from La Grange Bus Station to Biloxibus bus
    17h 27m
    $254–357

  4. Drive to Chattanooga Metropolitan Airport, fly to Gulfport-Biloxi Regional Airport

    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Gulfport-Biloxi Regional Airport (GPT)plane plane CHA - GPT
    5h 47m
    $109–422

  5. Fly Mcghee Tyson Airport to Mobile Regional Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Mobile Regional Airport (MOB)plane plane TYS - MOB
    2. Take the bus from Mobile Bus Station to Biloxi Transit Centerbus bus
    6h 3m
    $145–462

  6. Drive to Asheville Regional Airport, fly to Gulfport-Biloxi Regional Airport

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Gulfport-Biloxi Regional Airport (GPT)plane plane AVL - GPT
    6h 23m
    $117–437

  7. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Biloxi Amtrak Statrain train
    19h 24m
    $349–520

Mcghee Tyson Airport (TYS) to Gulfport-Biloxi Regional Airport (GPT) flights

Calendar75Weekly Planes
Duration5h 14mAverage Duration
Ticket$61Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Biloxi.ExpandLaunch map view
  • Distance: 500.6 mi
  • Duration: 4h 13m

What companies run services between Knoxville, TN, USA and Biloxi, MS, USA?

Delta, American Airlines, and United Airlines fly from Mcghee Tyson Airport (TYS) to Gulfport-Biloxi Regional Airport (GPT) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Biloxi via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Atlanta Bus Station, and La Grange Bus Station in around 17h 27m.

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