Rome2Rio

How to get fromKnoxville to Buffaloby plane, bus, train, or car

Find Transport to Buffalo

See all options

There are 5 ways to get from Knoxville to Buffalo by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    5h 7m
    $229–996

  2. Drive 682.6 mi

    cheapest
    1. Drive from Knoxville to Buffalocar car 682.6 mi
    11h 35m
    $125–180

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    21h 59m
    $250–453

  4. Fly to Rochester, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Rochester (ROC)plane plane TYS - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 44m
    $256–1,012

  5. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    24h 53m
    $275–522

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar94Weekly Planes
Duration5h 9mAverage Duration
Ticket$177Cheapest Price
See schedules

Questions & Answers

Map of how to get from Knoxville to Buffalo.ExpandLaunch map view
  • Distance: 593.1 mi
  • Duration: 5h 7m

What companies run services between Knoxville, TN, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Knoxville to Buffalo, NY via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, El Mercadito Grocery - Clarksville, IN, Louisville, KY Bus Station, and Cleveland, OH in around 24h 53m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers