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How to get fromKnoxville to Buffalo Airport (BUF)by plane, bus, train, car, or bus (Greyhound)

Find Transport to Buffalo Airport (BUF)

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There are 6 ways to get from Knoxville to Buffalo Airport (BUF) by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    4h 12m
    $207–917

  2. Drive 688.4 mi

    cheapest
    1. Drive from Knoxville to Buffalo-Airport-BUFcar car 688.4 mi
    11h 39m
    $126–182

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Rochestertrain train
    3. Take the bus from Rochester to Buffalobus bus
    22h 49m
    $258–473

  4. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Buffalobus bus
    22h 59m
    $248–417

  5. Bus via Louisville

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    26h 3m
    $280–550

  6. Bus via Reading

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Greyhound Station Cincinnatibus bus
    4. Take the bus from Cincinnati, OH to Buffalo, NYbus bus
    27h 32m
    $279–524

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar96Weekly Planes
Duration5h 9mAverage Duration
Ticket$158Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Buffalo Airport (BUF).ExpandLaunch map view
  • Distance: 579 mi
  • Duration: 4h 12m

What companies run services between Knoxville, TN, USA and Buffalo Airport (BUF), USA?

Southwest Airlines, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Knoxville to Buffalo Niagara International Airport via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Cleveland Bus Station, and Buffalo in around 22h 59m.

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