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How to get fromKnoxville to Buffalo Depew Stationby plane, bus, train, or car

Find Transport to Buffalo Depew Station

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There are 4 ways to get from Knoxville to Buffalo Depew Station by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    4h 18m
    $228–931

  2. Drive 685.8 mi

    cheapest
    1. Drive from Knoxville to Buffalo Depew Stationcar car 685.8 mi
    11h 37m
    $126–181

  3. Bus, train via New York

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    21h 44m
    $250–453

  4. Bus, train

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    4. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train
    25h 20m
    $315–595

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar96Weekly Planes
Duration5h 9mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 581.6 mi
  • Duration: 4h 18m

What companies run services between Knoxville, TN, USA and Buffalo Depew Station, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) hourly.

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