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How to get fromKnoxville to Carlisleby plane, bus, train, car, or bus (Flixbus)

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There are 5 ways to get from Knoxville to Carlisle by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT)plane plane TYS - MDT
    6h 41m
    $144–571

  2. Drive 518.9 mi

    cheapest
    1. Drive from Knoxville to Carlislecar car 518.9 mi
    8h 30m
    $95–137

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    18h 50m
    $196–295

  4. Fly to Philadelphia International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Philadelphia International Airport (PHL)plane plane TYS - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    7h 30m
    $211–842

  5. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York City Chinatown to Harrisburg Bus Stationbus bus FlixBus N2640
    22h 55m
    $129–171

Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT) flights

Calendar118Weekly Planes
Duration4h 45mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Carlisle.ExpandLaunch map view
  • Distance: 539.9 mi
  • Duration: 6h 41m

What companies run services between Knoxville, TN, USA and Carlisle, PA, USA?

United Airlines, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Knoxville Station Bay H to Hanover St & High St via Fountain City Superstop, Walmart, Knoxville, TN, New York City Chinatown, Harrisburg Bus Station, and Market Square Transfer Center in around 22h 55m.

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