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How to get fromKnoxville to Chicagoby plane, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Knoxville to Chicago by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Chicago O'Hare International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2h 58m
    $119–442

  2. Drive to Chattanooga Metropolitan Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Chicago O'Hare International Airport (ORD)plane plane CHA - ORD
    4h 35m
    $71–332

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    14h 54m
    $198–299

  4. Drive 527.1 mi

    1. Drive from Knoxville to Chicagocar car 527.1 mi
    9h 13m
    $97–139

  5. Fly Mcghee Tyson Airport to Chicago Midway International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2h 33m
    $129–482

Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) flights

Calendar87Weekly Planes
Duration3h 7mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Chicago.ExpandLaunch map view
  • Distance: 505.5 mi
  • Duration: 2h 58m

What companies run services between Knoxville, TN, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Chicago Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 14h 54m.

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