There are 5 ways to get from Knoxville to Chicago by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Mcghee Tyson Airport to Chicago Midway International Airport
best- Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane TYS - MDW
2h 36m$119–452Drive to Chattanooga Metropolitan Airport, fly to Chicago O'Hare International Airport
cheapest- Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car
- Fly from Chattanooga Metropolitan Airport (CHA) to Chicago O'Hare International Airport (ORD)plane CHA - ORD
4h 41m$65–310Bus
- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to Chicago Bus Stationbus Greyhound US0100
14h 47m$208–299Drive 527.1 mi
- Drive from Knoxville to Chicagocar 527.1 mi
9h 13m$91–131Fly Mcghee Tyson Airport to Chicago O'Hare International Airport
- Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane TYS - ORD
3h 8m$104–342
Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW) flights
Comparing Your Travel Options
The cheapest way to get from Knoxville to Chicago is to drive which costs $90 - $130 and takes 9h 13m.
The fastest way to get from Knoxville to Chicago is to fly which takes 2h 36m and costs $110 - $460.
No, there is no direct bus from Knoxville to Chicago station. However, there are services departing from Knoxville and arriving at Chicago Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 14h 47m.
The distance between Knoxville and Chicago is 486 miles. The road distance is 530.2 miles.
The best way to get from Knoxville to Chicago without a car is to bus which takes 14h 47m and costs $200 - $300.
It takes approximately 2h 36m to get from Knoxville to Chicago, including transfers.
Knoxville to Chicago bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to Chicago is to fly which takes 2h 36m and costs $110 - $460. Alternatively, you can bus, which costs $200 - $300 and takes 14h 47m.
Knoxville to Chicago bus services, operated by Wanda Coach, arrive at Nashville station.
Chicago is 1h behind Knoxville. It is currently 11:41 AM in Knoxville and 10:41 AM in Chicago.
What companies run services between Knoxville, TN, USA and Chicago, IL, USA?
Allegiant Air and Delta fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a vehicle from Knoxville to Chicago Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 14h 47m.
- Website
- delta.com
Flights from Mcghee Tyson Airport to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $80–430
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 19m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $55–300
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $55–310
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 44m
- When
- Every day
- Estimated price
- $55–310
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $55–310
- Website
- aa.com
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $45–270
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $60–320
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 19m
- When
- Every day
- Estimated price
- $45–280
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $60–320
- Website
- united.com
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- $45–270
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $45–280
- Website
- allegiantair.com
Flights from Mcghee Tyson Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 37m
- When
- Friday and Monday
- Estimated price
- $60–380
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Nashville Bus Station to Chicago Bus Station
- Ave. Duration
- 10h
- Frequency
- Every 4 hours
- Estimated price
- $85–130
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to Chicago Bus Station
- Ave. Duration
- 11h 25m
- Frequency
- Every 4 hours
- Estimated price
- $75–120
- Schedules at
- Flixbus USA
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Booking & Getting There
Yes, the driving distance between Knoxville to Chicago is 530 miles. It takes approximately 9h 13m to drive from Knoxville to Chicago.
There are 1307+ hotels available in Chicago.



