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How to get fromKnoxville to Columbiaby plane, bus (Greyhound, Flixbus), car, or bus

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There are 4 ways to get from Knoxville to Columbia by plane, bus (Greyhound, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU)plane plane TYS - COU
    5h 24m
    $217–732

  2. Drive 604.3 mi

    cheapest
    1. Drive from Knoxville to Columbiacar car 604.3 mi
    10h 10m
    $111–160

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Columbiabus bus
    15h 34m
    $199–299

  4. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take the bus from St Louis Bus Station to Columbiabus bus
    8h 10m
    $191–810

Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU) flights

Calendar53Weekly Planes
Duration5h 38mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Columbia.ExpandLaunch map view
  • Distance: 523.1 mi
  • Duration: 5h 24m

What companies run services between Knoxville, TN, USA and Columbia, MO, USA?

United Airlines and American Airlines fly from Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Columbia via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and St Louis Bus Station in around 15h 34m.

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