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How to get fromKnoxville to Deerfieldby plane, bus (Amtrak, Greyhound), car, train, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Knoxville to Deerfield by plane, bus (Amtrak, Greyhound), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Chicago O'Hare International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    4h 4m
    $135–470

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    6h 7m
    $80–335

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville to Chicago Union Stationbus bus
    16h 3m
    $212–325

  4. Drive 552.4 mi

    1. Drive from Knoxville to Deerfieldcar car 552.4 mi
    9h 47m
    $101–146

  5. Fly Mcghee Tyson Airport to Chicago Midway International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2. Take the train from Chicago Union Station to Deerfieldtrain train
    4h 14m
    $143–528

  6. Drive to Chattanooga Metropolitan Airport, fly to Chicago O'Hare International Airport

    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Chicago O'Hare International Airport (ORD)plane plane CHA - ORD
    5h 41m
    $107–490

  7. Bus via Chicago

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    16h 9m
    $212–325

Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) flights

Calendar85Weekly Planes
Duration3h 13mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Deerfield.ExpandLaunch map view
  • Distance: 511 mi
  • Duration: 4h 4m

What companies run services between Knoxville, TN, USA and Deerfield, IL, USA?

American Airlines, United Airlines, and Delta fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Deerfield via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville, Chicago Union Station, and Chicago Union Station in around 16h 3m.

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