What is the cheapest way to get from Knoxville to Des Moines?

The cheapest way to get from Knoxville to Des Moines is to drive which costs $140 - $220 and takes 13h 57m.

What is the fastest way to get from Knoxville to Des Moines?

The fastest way to get from Knoxville to Des Moines is to fly which takes 4h 59m and costs $160 - $600.

Is there a direct bus between Knoxville and Des Moines?

No, there is no direct bus from Knoxville to Des Moines. However, there are services departing from Knoxville and arriving at Des Moines via El Mezcal Grocery - Jackson, TN, Lafayette Rd & Office Plaza Blvd and Indianapolis Union Station. The journey, including transfers, takes approximately 26h 49m.

How far is it from Knoxville to Des Moines?

The distance between Knoxville and Des Moines is 676 miles. The road distance is 818.8 miles.

How do I travel from Knoxville to Des Moines without a car?

The best way to get from Knoxville to Des Moines without a car is to bus and train which takes 25h 1m and costs $390 - $600.

How long does it take to get from Knoxville to Des Moines?

It takes approximately 4h 59m to get from Knoxville to Des Moines, including transfers.

Where do I catch the Knoxville to Des Moines bus from?

Knoxville to Des Moines bus services, operated by Wanda Coach, depart from Knoxville station.

Bus or fly from Knoxville to Des Moines?

The best way to get from Knoxville to Des Moines is to fly which takes 4h 59m and costs $160 - $600. Alternatively, you can bus, which costs $310 - $420 and takes 26h 49m.

Where does the Knoxville to Des Moines bus arrive?

Knoxville to Des Moines bus services, operated by Wanda Coach, arrive at Jackson station.

What is the time difference between Knoxville and Des Moines?

Des Moines is 1h behind Knoxville. It is currently 6:00 AM in Knoxville and 5:00 AM in Des Moines.

Can I drive from Knoxville to Des Moines?

Yes, the driving distance between Knoxville to Des Moines is 819 miles. It takes approximately 13h 57m to drive from Knoxville to Des Moines.

Where can I stay near Des Moines?

There are 255+ hotels available in Des Moines.

Knoxville to Des Moines - 6 ways to travel via train, plane, bus, and car

How to get fromKnoxville to Des Moines

Travel from

See all options

Search accommodation with Expedia

There are 6 ways to get from Knoxville to Des Moines by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Mcghee Tyson Airport
best
1. Fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM)plane TYS - DSM
4h 59m
$160–580
Drive to Chattanooga Metropolitan Airport, fly
cheapest
1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car
2. Fly from Chattanooga Metropolitan Airport (CHA) to Des Moines (DSM)plane CHA - DSM
6h 5m
$112–470
Bus, train
1. Take the bus from Knoxville to Memphis - Summer Avebus Nyc
2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus
3. Take the train from St. Louis to Kansas Citytrain
4. Take the bus from Kansas City Bus Station to Des Moinesbus
25h 1m
$399–600
Drive 814.1 mi
1. Drive from Knoxville to Des Moinescar 814.1 mi
13h 57m
$149–215
Drive to Asheville Regional Airport, fly
1. Drive from Knoxville to Asheville-Airport-AVLcar
2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)plane AVL - DSM
6h 47m
$120–475
Bus
1. Take the bus from Knoxville to Jacksonbus Nyc
2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus
3. Take the bus from Indianapolis Union Station to Des Moinesbus
26h 49m
$311–412

Mcghee Tyson Airport (TYS) to Des Moines (DSM) flights

91Weekly Planes

5h 42mAverage Duration

$89Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Knoxville to Des Moines.

Launch map view

Distance: 672.4 mi
Duration: 4h 59m

What companies run services between Knoxville, TN, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Knoxville to Des Moines via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Lafayette Rd & Office Plaza Blvd, Ctc-R, and Indianapolis Union Station in around 26h 49m.

Airlines

Train operators

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.