What is the cheapest way to get from Knoxville to Des Moines?

The cheapest way to get from Knoxville to Des Moines is to drive which costs $140 - $220 and takes 13h 57m.

What is the fastest way to get from Knoxville to Des Moines?

The fastest way to get from Knoxville to Des Moines is to fly which takes 4h 42m and costs $250 - $1,100.

Is there a direct bus between Knoxville and Des Moines?

No, there is no direct bus from Knoxville to Des Moines. However, there are services departing from Knoxville and arriving at Des Moines via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13, Nashville Bus Station, Louisville Bus Station and Indianapolis Union Station. The journey, including transfers, takes approximately 21h 18m.

How far is it from Knoxville to Des Moines?

The distance between Knoxville and Des Moines is 676 miles. The road distance is 818.8 miles.

How do I travel from Knoxville to Des Moines without a car?

The best way to get from Knoxville to Des Moines without a car is to bus via Indianapolis which takes 21h 18m and costs $250 - $410.

How long does it take to get from Knoxville to Des Moines?

It takes approximately 4h 42m to get from Knoxville to Des Moines, including transfers.

Where do I catch the Knoxville to Des Moines bus from?

Knoxville to Des Moines bus services, operated by Wanda Coach, depart from Knoxville station.

Bus or fly from Knoxville to Des Moines?

The best way to get from Knoxville to Des Moines is to fly which takes 4h 42m and costs $250 - $1,100. Alternatively, you can bus via Indianapolis, which costs $250 - $410 and takes 21h 18m.

Where does the Knoxville to Des Moines bus arrive?

Knoxville to Des Moines bus services, operated by Wanda Coach, arrive at Nashville station.

What is the time difference between Knoxville and Des Moines?

Des Moines is 1h behind Knoxville. It is currently 5:16 AM in Knoxville and 4:16 AM in Des Moines.

Can I drive from Knoxville to Des Moines?

Yes, the driving distance between Knoxville to Des Moines is 819 miles. It takes approximately 13h 57m to drive from Knoxville to Des Moines.

Where can I stay near Des Moines?

There are 245+ hotels available in Des Moines.

Knoxville to Des Moines - 7 ways to travel via plane, bus, and car

How to get fromKnoxville to Des Moines

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There are 7 ways to get from Knoxville to Des Moines by plane, bus (Greyhound, Amtrak, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Mcghee Tyson Airport
best
1. Fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM)plane TYS - DSM
4h 42m
$254–1,038
Drive 814.1 mi
cheapest
1. Drive from Knoxville to Des Moinescar 814.1 mi
13h 57m
$149–215
Bus via Indianapolis
1. Take the bus from Knoxville to Nashvillebus Nyc
2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus
3. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus
4. Take the bus from Indianapolis Union Station to Des Moinesbus
21h 18m
$252–409
Drive to Chattanooga Metropolitan Airport, fly
1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car
2. Fly from Chattanooga Metropolitan Airport (CHA) to Des Moines (DSM)plane CHA - DSM
6h 24m
$246–1,148
Drive to Asheville Regional Airport, fly
1. Drive from Knoxville to Asheville-Airport-AVLcar
2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)plane AVL - DSM
6h 44m
$179–753
Bus
1. Take the bus from Knoxville to Memphis - Summer Avebus Nyc
2. Take the bus from Memphis Bus Station to Kansas Citybus
3. Take the bus from Kansas City to Des Moinesbus
24h 48m
$305–421
Bus #2
1. Take the bus from Knoxville to Jacksonbus Nyc
2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus
3. Take the bus from Indianapolis to Des Moinesbus
28h 6m

Mcghee Tyson Airport (TYS) to Des Moines (DSM) flights

89Weekly Planes

5h 12mAverage Duration

$189Cheapest Price

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Questions & Answers

Map of how to get from Knoxville to Des Moines.

Launch map view

Distance: 672.4 mi
Duration: 4h 42m

What companies run services between Knoxville, TN, USA and Des Moines, IA, USA?

Delta, United Airlines, and American Airlines fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Knoxville to Des Moines via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Louisville Bus Station, and Indianapolis Union Station in around 21h 18m.

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