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How to get fromKnoxville to Destinby plane, bus, taxi, or car

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There are 6 ways to get from Knoxville to Destin by plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Destin–Fort Walton Beach Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS)plane plane TYS - VPS
    2h 6m
    $167–562

  2. Drive  502.3 mi

    cheapest
    1. Drive from Knoxville to Destincar car 502.3 mi
    9h 12m
    $92–133

  3. Bus, taxi

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    16h 35m
    $375–500

  4. Fly to Northwest Florida Beaches International Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Northwest Florida Beaches International Airport (ECP)plane plane TYS - ECP
    2. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    4h 49m
    $267–687

  5. Fly to Pensacola International Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Pensacola International Airport (PNS)plane plane TYS - PNS
    2. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    4h 41m
    $227–557

  6. Bus, taxi via Sandy Springs

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Omni Nashville Hotel to Grand Hyatt Atlanta in Buckheadbus bus
    3. Take the bus from Atlanta to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    17h 56m
    $503–634

Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar21Weekly Planes
Duration2h 43mAverage Duration
Ticket$71Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Destin.ExpandLaunch map view
  • Distance: 424.1 mi
  • Duration: 2h 6m

What companies run services between Knoxville, TN, USA and Destin, FL, USA?

Allegiant Air and Delta fly from Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS) 3 times a day.

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