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How to get fromKnoxville to Effinghamby bus, train, car, plane, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Knoxville to Effingham by bus, train, car, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the train from Carbondale to Effingham Stationtrain train
    11h 23m
    $198–299

  2. Drive 412.8 mi

    cheapest
    1. Drive from Knoxville to Effinghamcar car 412.8 mi
    8h 25m
    $76–109

  3. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take the bus from St Louis Bus Station to Effinghambus bus
    6h 55m
    $186–805

  4. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Effinghambus bus
    13h 44m
    $194–299

  5. Fly to University Of Illinois Willard Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to University Of Illinois Willard Airport (CMI)plane plane TYS - CMI
    2. Take the train from Champaign-Urbana to Effingham Stationtrain train
    6h 41m
    $193–690

  6. Fly to Decatur Airport, bus, train

    1. Fly from Mcghee Tyson Airport (TYS) to Decatur Airport (DEC)plane plane TYS - DEC
    2. Take the bus from Decatur Downtown Transportation Center to Champaign Intermodal Trans Ctrbus bus
    3. Take the train from Champaign-Urbana to Effingham Stationtrain train
    9h 33m
    $201–697

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar125Weekly Planes
Duration4h 54mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Effingham.ExpandLaunch map view
  • Distance: 505.2 mi
  • Duration: 11h 23m

What companies run services between Knoxville, TN, USA and Effingham, IL, USA?

You can take a vehicle from Knoxville to Effingham via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and St Louis Bus Station in around 13h 44m.

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Train operators
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