There are 4 ways to get from Knoxville to Florence by plane, car, shuttle, bus, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Mcghee Tyson Airport (TYS) to Florence Regional Airport (FLO)plane TYS - FLO
3h 55m$132–510Drive 339.9 mi
cheapest- Drive from Knoxville to Florencecar 339.9 mi
5h 52m$62–90Drive, shuttle, bus
- Drive from Knoxville to Hot Springscar
- Take a shuttle bus from Hot Springs to Black Bear Resort
- Take a shuttle bus from Black Bear Resort to Boone
- Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus
- Take the bus from Charlotte Bus Station to Camdenbus
- Take the bus from Camden to Florence Bus Stationbus
12h 54m$373–433Bus
- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Florence Bus Stationbus
16h 23m$208–324
Mcghee Tyson Airport (TYS) to Florence Regional Airport (FLO) flights
Questions & Answers
The cheapest way to get from Knoxville to Florence is to drive which costs $60 - $90 and takes 5h 52m.
The fastest way to get from Knoxville to Florence is to fly which takes 3h 55m and costs $130 - $550.
No, there is no direct bus from Knoxville to Florence station. However, there are services departing from Knoxville and arriving at Florence Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13, Nashville Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 16h 23m.
The distance between Knoxville and Florence is 282 miles. The road distance is 341.9 miles.
The best way to get from Knoxville to Florence without a car is to bus which takes 16h 23m and costs $200 - $330.
It takes approximately 3h 55m to get from Knoxville to Florence, including transfers.
Knoxville to Florence bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to Florence is to fly which takes 3h 55m and costs $130 - $550. Alternatively, you can bus, which costs $200 - $330 and takes 16h 23m.
Knoxville to Florence bus services, operated by Wanda Coach, arrive at Nashville station.
Yes, the driving distance between Knoxville to Florence is 342 miles. It takes approximately 5h 52m to drive from Knoxville to Florence.
What companies run services between Knoxville, TN, USA and Florence, SC, USA?
American Airlines flies from Mcghee Tyson Airport (TYS) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a vehicle from Knoxville to Florence Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Atlanta Bus Station in around 16h 23m.
- Website
- aa.com
Flights from Mcghee Tyson Airport to Florence Regional Airport via Charlotte
- Ave. Duration
- 4h 21m
- When
- Every day
- Estimated price
- $65–430
- Phone
- +1-423-725-5988
- Website
- Black Bear Resort Shuttle
Shuttle from Hot Springs to Black Bear Resort
- Ave. Duration
- 1h 30m
- Frequency
- On demand
- Estimated price
- $136
- Website
- Black Bear Resort Shuttle
Shuttle from Black Bear Resort to Boone
- Ave. Duration
- 1h
- Frequency
- On demand
- Estimated price
- $86
- Website
- Black Bear Resort Shuttle
- Phone
- +1 828-327-2340
- [email protected]
- Website
- Hickory Hop
Bus from ASU Peacock Hall Boone to Charlotte Airport
- Ave. Duration
- 2h 30m
- Frequency
- Every 4 hours
- Estimated price
- $90–110
- Schedules at
- Hickory Hop
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Charlotte Bus Station to Camden
- Ave. Duration
- 1h 35m
- Frequency
- Twice daily
- Estimated price
- $11–23
- Website
- Greyhound
Bus from Camden to Florence Bus Station
- Ave. Duration
- 1h
- Frequency
- 4 times a day
- Estimated price
- $7–14
- Website
- Greyhound
Bus from Nashville Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- Hourly
- Estimated price
- $35–70
- Website
- Greyhound
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- 4 times a day
- Estimated price
- $40–85
- Website
- Greyhound
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h
- Frequency
- 5 times a day
- Estimated price
- $35–65
- Schedules at
- Flixbus USA
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