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How to get fromKnoxville to Florida Keysby plane, car, shuttle, taxi, bus, or train

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There are 6 ways to get from Knoxville to Florida Keys by plane, car, shuttle, taxi, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Key West International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    5h 13m
    $194–491

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    7h 5m
    $159–456

  3. Drive, shuttle, taxi, bus, train

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Washington Union Stationbus bus
    5. Take the train from Washington Union Station to Miami Amtrak Stationtrain train
    6. Take the bus from Miami Airport Station to Big Pine Keybus bus
    43h 32m
    $942–1,403

  4. Drive  982.4 mi

    1. Drive from Knoxville to Florida Keyscar car 982.4 mi
    17h 49m
    $180–259

  5. Fly Mcghee Tyson Airport to Miami International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane plane TYS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 3m
    $274–631

  6. Fly Mcghee Tyson Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 19m
    $304–701

Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) flights

Calendar41Weekly Planes
Duration4h 12mAverage Duration
Ticket$62Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Florida Keys.ExpandLaunch map view
  • Distance: 822.4 mi
  • Duration: 5h 13m

What companies run services between Knoxville, TN, USA and Florida Keys, FL, USA?

Allegiant Air, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) every 4 hours.

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