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How to get fromKnoxville to Florida Panhandleby plane, car, or bus

Find Transport to Florida Panhandle

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There are 6 ways to get from Knoxville to Florida Panhandle by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tallahassee, drive

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Tallahassee (TLH)plane plane TYS - TLH
    2. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    4h 39m
    $157–632

  2. Drive 463.5 mi

    cheapest
    1. Drive from Knoxville to Florida Panhandlecar car 463.5 mi
    9h 1m
    $85–123

  3. Bus, drive

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Drive from Tallahassee to Florida Panhandlecar car
    15h 41m
    $218–335

  4. Fly to Northwest Florida Beaches International Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Northwest Florida Beaches International Airport (ECP)plane plane TYS - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Florida Panhandlecar car
    4h 43m
    $142–532

  5. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS)plane plane TYS - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Florida Panhandlecar car
    3h 50m
    $150–544

  6. Fly to Dothan Regional Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Dothan Regional Airport (DHN)plane plane TYS - DHN
    2. Drive from Dothan Regional Airport (DHN) to Florida Panhandlecar car
    5h 22m
    $141–519

Mcghee Tyson Airport (TYS) to Tallahassee (TLH) flights

Calendar68Weekly Planes
Duration4h 44mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Florida Panhandle.ExpandLaunch map view
  • Distance: 443.3 mi
  • Duration: 4h 39m

What companies run services between Knoxville, TN, USA and Florida Panhandle, FL, USA?

There is no direct connection from Knoxville to Florida Panhandle. However, you can take the taxi to Mcghee Tyson Airport (TYS) airport, fly to Tallahassee (TLH), then drive to Florida Panhandle. Alternatively, you can take a vehicle from Knoxville to Florida Panhandle via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Tallahassee in around 15h 41m.

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Bus operators

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