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How to get fromKnoxville to Fort Myersby plane, bus (Greyhound, Flixbus), car, taxi, or bus

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There are 8 ways to get from Knoxville to Fort Myers by plane, bus (Greyhound, Flixbus), car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Ft. Myers

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Ft. Myers (RSW)plane plane TYS - RSW
    5h 56m
    $170–672

  2. Drive 753.9 mi

    cheapest
    1. Drive from Knoxville to Fort Myerscar car 753.9 mi
    13h 28m
    $138–199

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    3. Take the bus from Clarksville Park & Ride to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    5. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    26h
    $269–424

  4. Fly Mcghee Tyson Airport to Punta Gorda Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Punta Gorda Airport (PGD)plane plane TYS - PGD
    2. Take the taxi from Punta Gorda Airport (PGD) to Fort Myerstaxi taxi
    2h 47m
    $237–712

  5. Fly Mcghee Tyson Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    2. Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stopbus bus
    5h 49m
    $188–707

  6. Drive to Asheville Regional Airport, fly to Punta Gorda Airport, taxi

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Punta Gorda Airport (PGD)plane plane AVL - PGD
    3. Take the taxi from Punta Gorda Airport (PGD) to Fort Myerstaxi taxi
    4h 35m
    $167–487

  7. Fly Mcghee Tyson Airport to Orlando Sanford, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Fort Myerscar car
    5h 32m
    $177–617

  8. Fly Mcghee Tyson Airport to Orlando, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane plane TYS - MCO
    2. Take the bus from Orlando to Fort Myers Bus Stopbus bus
    9h 18m
    $184–634

Mcghee Tyson Airport (TYS) to Ft. Myers (RSW) flights

Calendar75Weekly Planes
Duration5h 13mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Fort Myers.ExpandLaunch map view
  • Distance: 681.5 mi
  • Duration: 5h 56m

What companies run services between Knoxville, TN, USA and Fort Myers, FL, USA?

Delta, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Ft. Myers (RSW) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Fort Myers Bus Stop via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 5Th Ave - Bay 11, Clarksville Exit 11 Park And Ride, Clarksville Park & Ride, Atlanta Bus Station, and Tampa Bus Station in around 26h.

Airlines
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