Rome2Rio

How to get fromKnoxville to Fort Pierceby plane, car, shuttle, or bus

Find Transport to Fort Pierce

See all options

There are 7 ways to get from Knoxville to Fort Pierce by plane, car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Melbourne International Airport, drive

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Melbourne International Airport (MLB)plane plane TYS - MLB
    2. Drive from Melbourne International Airport (MLB) to Fort Piercecar car
    5h 50m
    $147–552

  2. Drive  742.8 mi

    cheapest
    1. Drive from Knoxville to Fort Piercecar car 742.8 mi
    12h 30m
    $136–196

  3. Drive, shuttle, bus

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Booneshuttle bus
    4. Take the bus from Boone to Charlottebus bus
    5. Take the bus from Charlotte Bus Station to Jacksonvillebus bus
    6. Take the bus from Jacksonville to Fort Piercebus bus
    24h 24m
    $370–460

  4. Fly to Orlando Sanford, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Fort Piercecar car
    4h 8m
    $154–552

  5. Fly to Orlando, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane plane TYS - MCO
    2. Take a shuttle bus from Orlando Airport to Fort Pierce, FL - Dunkin' Donutsshuttle bus
    5h 4m
    $238–684

  6. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus
    5h 27m
    $204–684

  7. Fly to Miami International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane plane TYS - MIA
    2. Take the bus from Miami Airport to Fort Piercebus bus
    6h 12m
    $204–644

Mcghee Tyson Airport (TYS) to Melbourne International Airport (MLB) flights

Calendar45Weekly Planes
Duration4h 57mAverage Duration
Ticket$83Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Knoxville to Fort Pierce.ExpandLaunch map view
  • Distance: 634.8 mi
  • Duration: 5h 50m

What companies run services between Knoxville, TN, USA and Fort Pierce, FL, USA?

There is no direct connection from Knoxville to Fort Pierce. However, you can take the taxi to Mcghee Tyson Airport (TYS) airport, fly to Melbourne International Airport (MLB), then drive to Fort Pierce. Alternatively, you can take a vehicle from Knoxville to Fort Pierce via Hot Springs, Black Bear Resort, Boone, Boone, Charlotte Bus Station, Jacksonville, and Fort Pierce in around 24h 24m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound