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How to get fromKnoxville to Gainesvilleby plane, bus (Greyhound, Flixbus), car, bus, or shuttle

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There are 8 ways to get from Knoxville to Gainesville by plane, bus (Greyhound, Flixbus), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gainesville Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Gainesville Regional Airport (GNV)plane plane TYS - GNV
    4h 59m
    $139–539

  2. Drive 527.6 mi

    cheapest
    1. Drive from Knoxville to Gainesvillecar car 527.6 mi
    9h 5m
    $97–140

  3. Bus via Atlanta

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    15h 43m
    $218–334

  4. Fly to Orlando Sanford, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    4h 17m
    $162–587

  5. Fly to Jacksonville, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Jacksonville (JAX)plane plane TYS - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    5h 40m
    $149–578

  6. Fly to Orlando, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane plane TYS - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    5h 37m
    $173–604

  7. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Gainesvillebus bus
    17h 54m
    $232–359

  8. Drive, shuttle, bus

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Booneshuttle bus
    4. Take the bus from Boone to Charlottebus bus
    5. Take the bus from Charlotte Bus Station to Jacksonvillebus bus
    6. Take the bus from Jacksonville to Gainesvillebus bus
    20h 4m

Mcghee Tyson Airport (TYS) to Gainesville Regional Airport (GNV) flights

Calendar52Weekly Planes
Duration4h 30mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Gainesville.ExpandLaunch map view
  • Distance: 454.1 mi
  • Duration: 4h 59m

What companies run services between Knoxville, TN, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Mcghee Tyson Airport (TYS) to Gainesville Regional Airport (GNV) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Gainesville via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Atlanta Bus Station in around 15h 43m.

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