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How to get fromKnoxville to Greenvilleby plane, train, taxi, bus, or car

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There are 5 ways to get from Knoxville to Greenville by plane, train, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport, train, taxi

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    3. Take the taxi from SHILOH-SCOTT station to Greenvilletaxi taxi
    5h 50m
    $260–890

  2. Drive 467.4 mi

    cheapest
    1. Drive from Knoxville to Greenvillecar car 467.4 mi
    8h 2m
    $86–124

  3. Bus, train, taxi

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the train from Carbondale to Centralia Amtraktrain train
    4. Take the taxi from Centralia Amtrak to Greenvilletaxi taxi
    11h 43m
    $265–374

  4. Fly to Abraham Lincoln Capital Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Abraham Lincoln Capital Airport (SPI)plane plane TYS - SPI
    2. Drive from Abraham Lincoln Capital Airport (SPI) to Greenvillecar car
    6h 27m
    $170–637

  5. Fly to Midamerica St. Louis Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Midamerica St. Louis Airport (BLV)plane plane TYS - BLV
    2. Take the taxi from Midamerica St. Louis Airport (BLV) to Greenvilletaxi taxi
    8h 6m
    $307–927

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar130Weekly Planes
Duration4h 55mAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Greenville.ExpandLaunch map view
  • Distance: 496.3 mi
  • Duration: 5h 50m

What companies run services between Knoxville, TN, USA and Greenville, IL, USA?

There is no direct connection from Knoxville to Greenville. However, you can take the taxi to Mcghee Tyson Airport (TYS) airport, fly to Lambert–St. Louis International Airport (STL), walk to LAMBERT AIRPORT TERMINAL #1 station, take the train to SHILOH-SCOTT station, then take the taxi to Greenville. Alternatively, you can take the taxi to Knoxville, take the bus to Nashville, walk to Charlotte Pike & Lellyett St Eb, take the line 50 bus to Central 5Th Ave - Bay 1, walk to Central 4Th Ave - Bay 13, take the line 55 bus to Fulton Station Outbound, walk to Nashville Bus Station, take the bus to Carbondale Intermodal Station, walk to Carbondale, take the train to Centralia Amtrak, then take the taxi to Greenville.

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